文章：

提升pT3上尿路尿路上皮癌风险分层：聚焦浸润模式研究

Improving Risk Stratification in pT3 Upper Tract Urothelial Carcinoma: A Focus on Invasion Patterns

原文发布日期：8 March 2025

DOI: 10.3390/cancers17060923

类型: Article

开放获取: 是

英文摘要：

Purpose:Existing T3 subclassifications for upper tract urothelial cancer (UTUC) are limited by heterogeneity and a primary focus on renal pelvis tumors. Our study aimed to propose a novel pT3 subclassification system specifically tailored to pT3 UTUC patients.Materials and Methods:This study analyzed 120 pT3 UTUC cases from a Taiwanese multicenter registry, using a standardized pathology report and a single pathologist for evaluation.Results:Univariate analysis revealed survival differences based on existing subclassifications. Multivariate analysis identified concurrent fat and parenchyma invasion as an independent predictor of worse overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS).Conclusions: This study proposes a novel pT3 subclassification incorporating fat and parenchyma invasion, applicable to all UTUC sites. This subclassification may improve risk stratification, guide treatment decisions, and ultimately enhance patient outcomes.

摘要翻译： 

目的：目前上尿路尿路上皮癌（UTUC）的T3亚分类存在异质性且主要针对肾盂肿瘤的局限性。本研究旨在提出一种专门针对pT3 UTUC患者的新型pT3亚分类系统。 材料与方法：本研究分析了来自台湾多中心登记的120例pT3 UTUC病例，采用标准化病理报告并由单一病理学家进行评估。 结果：单变量分析显示，基于现有亚分类的生存率存在差异。多变量分析确定，同时存在脂肪和实质浸润是总体生存率（OS）、癌症特异性生存率（CSS）和无病生存率（DFS）较差的独立预测因素。 结论：本研究提出了一种包含脂肪和实质浸润的新型pT3亚分类，适用于所有UTUC部位。该亚分类可能改善风险分层，指导治疗决策，并最终提升患者预后。

原文链接：

Improving Risk Stratification in pT3 Upper Tract Urothelial Carcinoma: A Focus on Invasion Patterns