Background:Cervical cancer, primarily driven by persistent high-risk human papillomavirus (HPV) infections, remains a significant global health challenge. Systemic inflammatory markers, such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and lymphocyte/monocyte ratio (LMR), may reflect disease progression. This study examines the association between these markers and p16 positivity in cervical intraepithelial neoplasia (CIN) cases.Methods:This retrospective analysis included 395 patients undergoing LEEP conization. Data on HPV status, p16 immunostaining, and hematological parameters were collected. Statistical analyses, including Mann–Whitney U and chi-square tests, assessed relationships between markers and outcomes, with significance set atp< 0.05.Results:Elevated NLR was significantly associated with p16 positivity (p= 0.011) and HPV DNA positivity (p= 0.04). HPV-positive individuals showed higher mean NLR (2.15) compared to HPV-negative individuals (1.61). Receiver operating characteristic (ROC) analysis demonstrated moderate diagnostic accuracy for NLR (AUC = 0.610), highlighting its potential as a biomarker. No significant associations were observed for PLR or LMR with p16 positivity. These findings suggest systemic inflammation, indicated by NLR, contributes to HPV persistence and CIN progression.Conclusions:NLR is a valuable prognostic biomarker for HPV-related cervical disease, correlating with both p16 and HPV DNA positivity. Incorporating hematological and immunohistochemical markers may enhance personalized cervical cancer management.
背景：宫颈癌主要由持续高危型人乳头瘤病毒（HPV）感染驱动，仍是全球重大健康挑战。系统性炎症标志物，如中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）和淋巴细胞/单核细胞比值（LMR），可能反映疾病进展。本研究探讨了宫颈上皮内瘤变（CIN）病例中这些标志物与p16阳性之间的关联。 方法：本回顾性分析纳入395例接受LEEP锥切术的患者。收集HPV状态、p16免疫组化染色及血液学参数数据。采用Mann–Whitney U检验和卡方检验等统计方法分析标志物与结局的关系，显著性水平设定为p < 0.05。 结果：NLR升高与p16阳性（p = 0.011）及HPV DNA阳性（p = 0.04）显著相关。HPV阳性个体的平均NLR（2.15）高于HPV阴性个体（1.61）。受试者工作特征（ROC）分析显示NLR具有中等诊断准确性（AUC = 0.610），凸显其作为生物标志物的潜力。PLR和LMR与p16阳性未观察到显著关联。这些发现表明，以NLR为代表的系统性炎症促进了HPV持续感染和CIN进展。 结论：NLR是HPV相关宫颈疾病的重要预后生物标志物，与p16及HPV DNA阳性均相关。整合血液学和免疫组化标志物可能有助于优化宫颈癌的个体化管理。
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