Background/Objectives: Sleep issues are common in the general population, and these problems occur even more frequently for people with cancer. Sleep problems may pre-exist a patient’s cancer diagnosis, and there is a growing interest in understanding the impact of sleep on cancer development and progression. Sleep disorders may impact cancer through altered metabolism, impacts on immune response, and alterations in hormones and gene expression. Sleep disorders may also arise after, or be aggravated by, an individual’s cancer and cancer treatment. Treating a person with cancer’s sleep disorder may help improve their healing, mental health, cognition, and overall resilience.Methods:Studies examining a variety of aspects of the relationship between sleep and cancer were found by searching the National Library of Medicine and characterized by their specific information provided on the relationship between sleep and cancer.Results:This review article summarizes our current understanding of the complex inter-relationship between sleep and cancer, the underlying mechanisms that create these connections, and the methods and impact of treating sleep issues in cancer patients. The article also outlines an approach to sleep complaints for clinicians caring for patients with cancer.Conclusions:Significant research is still needed to understand the full relationship between sleep disorders and cancer. The impact of sleep issues on cancer and of cancer on sleep appears to be specific to the tissue and the molecular type of cancer. The treatment of sleep disorders is multimodal, and offers a promising avenue to improve the health and quality of life of cancer patients.
背景/目的：睡眠问题在普通人群中较为常见，而在癌症患者中发生率更高。睡眠问题可能先于癌症诊断存在，学界日益关注睡眠对癌症发生与进展的影响。睡眠障碍可能通过改变新陈代谢、影响免疫反应以及干扰激素与基因表达等途径影响癌症进程。同时，癌症本身及其治疗也可能诱发或加重睡眠障碍。对癌症患者睡眠障碍的干预可能有助于促进其康复、改善心理健康、提升认知功能并增强整体抗逆能力。 方法：通过检索美国国家医学图书馆数据库，筛选并整合了探讨睡眠与癌症关联的多维度研究，依据其提供的睡眠与癌症关系的具体信息进行特征分析。 结果：本文综述了当前对睡眠与癌症复杂相互关系的认知，阐释了二者关联的内在机制，并系统总结了癌症患者睡眠问题的干预方法及其影响。同时为临床医生提供了针对癌症患者睡眠主诉的诊疗思路。 结论：睡眠障碍与癌症的完整关联机制仍需深入研究。睡眠问题对癌症的影响及癌症对睡眠的影响具有组织特异性和癌症分子分型特异性。睡眠障碍的治疗需采取多模式策略，这为改善癌症患者健康与生活质量提供了具有前景的干预方向。
肿瘤(癌症)患者之家