文章：

靶向二氢神经酰胺的生物活性化合物及其在癌症治疗中的治疗潜力

Bioactive Compounds Targeting Dihydroceramide and Their Therapeutic Potential in Cancer Treatment

原文发布日期：6 March 2025

DOI: 10.3390/cancers17050909

类型: Article

开放获取: 是

英文摘要：

Dihydroceramide (dhCer) was previously considered an inactive precursor of ceramide, a well-known sphingoid base involved in regulating apoptosis and cell death. However, recent studies have shown that dhCer plays a crucial role in various important cellular responses. In this review, we summarize the latest findings on the biological functions of dhCer and the enzymes involved in its biosynthesis. We specifically focus on the emerging evidence implicating dhCer in cancer, as well as its role in regulating key processes such as cell cycle arrest, autophagy, apoptosis, ER stress, and oxidative stress. Furthermore, we discuss bioactive compounds that can modulate dhCer levels in cancer cells, highlighting their potential therapeutic applications in counteracting cancer progression. This review emphasizes the growing recognition of dhCer as a bioactive sphingolipid metabolite with significant potential for cancer therapy.

摘要翻译： 

二氢神经酰胺（dhCer）曾被视为神经酰胺的非活性前体，而神经酰胺是参与调控细胞凋亡与死亡的重要鞘氨醇碱基。然而，近期研究表明，dhCer在多种关键细胞应答过程中发挥着重要作用。本综述系统总结了关于dhCer生物学功能及其生物合成相关酶的最新研究进展，重点聚焦于dhCer在癌症中的新兴证据，及其在细胞周期阻滞、自噬、凋亡、内质网应激和氧化应激等关键调控过程中的作用。此外，我们探讨了能够调节癌细胞中dhCer水平的生物活性化合物，并着重阐述了这些化合物在抑制癌症进展方面的潜在治疗价值。本综述强调，dhCer作为一种具有重要癌症治疗潜力的生物活性鞘脂代谢物，正日益受到学界重视。

原文链接：

Bioactive Compounds Targeting Dihydroceramide and Their Therapeutic Potential in Cancer Treatment