The human papillomavirus (HPV) has been associated with the carcinogenesis of cutaneous squamous cell carcinoma (cSCC), especially in immunosuppressed patients. This article reviews the microbiology of HPV and its role in tissue tropism, invasion, and oncogenesis. It also describes possible HPV oncogenic ability due to the inactivation of the host p53 and retinoblastoma protein (pRb) by HPV oncoproteins E6 and E7, producing a suppression of cell cycle checkpoints and uncontrolled cell proliferation that may eventually result in invasive carcinoma. We will focus on β-HPV types and their role in epidermodysplasia verruciformis (EV), as well as α types and their ability to cause cutaneous and mucosal pathology. We also intend to examine the clinical characteristics of cSCC related to HPV and host immunosuppression conditions such as solid organ transplant in order to provide management guidelines for patients with cSCC associated with HPV based on available data. Other topics addressed in this article include particular locations of cSCC, such as nails; the prognosis; the recurrence; therapeutic modalities; and the role of HPV vaccines.
人乳头瘤病毒（HPV）与皮肤鳞状细胞癌（cSCC）的致癌机制相关，尤其在免疫抑制患者中表现显著。本文综述了HPV的微生物学特征及其在组织趋向性、侵袭和致癌过程中的作用，同时阐述了HPV致癌蛋白E6和E7通过灭活宿主p53和视网膜母细胞瘤蛋白（pRb），导致细胞周期检查点抑制和细胞增殖失控，最终可能引发浸润性癌变的潜在致癌机制。我们将重点关注β型HPV在疣状表皮发育不良（EV）中的作用，以及α型HPV引发皮肤和黏膜病变的能力。此外，本文旨在分析HPV相关cSCC的临床特征及宿主免疫抑制状态（如实体器官移植）的影响，以期基于现有数据为HPV相关cSCC患者提供诊疗指导。文中还探讨了cSCC的特殊发病部位（如甲周）、预后、复发情况、治疗模式以及HPV疫苗的作用等议题。
Human Papillomavirus-Related Cutaneous Squamous Cell Carcinoma
肿瘤(癌症)患者之家