Background/Objectives: Haematologic cancers, such acute leukaemia, lymphoma, and multiple myeloma, are associated with high morbidity and mortality rates, often exacerbated by malnutrition and functional decline. This study aims to evaluate the prognostic value of bioimpedance phase angle (PhA) and hand grip strength (HGS) as nutritional and clinical markers for predicting 12-month mortality in hospitalized patients with haematologic cancers.Methods: A retrospective observational study was conducted on 121 patients admitted to Hospital Quironsalud Málaga between January 2019 and June 2021. PhA was measured using bioelectrical impedance analysis (BIA) and HGS was assessed using a dynamometer. Nutritional status was evaluated through Subjective Global Assessment (SGA) and the Global Leadership Initiative on Malnutrition (GLIM) criteria. The primary outcome was 12-month mortality, analysed using ROC curves, Kaplan–Meier survival estimates, and multivariate logistic regression models.Results: Lower PhA (<3.8° for females, <5.4° for males) and reduced HGS (<17 kg for females, <28 kg for males) were significantly associated with higher 12-month mortality (p< 0.001). The optimal PhA cut-off showed high sensitivity (85.5%) and specificity (62.2%). Multivariate analysis confirmed PhA as an independent predictor of mortality (OR = 0.417,p= 0.023). Patients with lower PhA and HGS values exhibited reduced survival rates, emphasizing the importance of these markers in clinical practice.Conclusions: PhA and HGS are reliable, non-invasive tools for assessing prognosis in haematologic cancer patients. Incorporating these markers into routine care could improve risk stratification, guide nutritional interventions, and enhance patient outcomes.
背景/目的：血液系统恶性肿瘤，如急性白血病、淋巴瘤和多发性骨髓瘤，常伴随高发病率与死亡率，而营养不良和功能衰退往往加剧这一状况。本研究旨在评估生物电阻抗相位角（PhA）和握力（HGS）作为营养与临床标志物，在预测血液系统恶性肿瘤住院患者12个月死亡率方面的预后价值。 方法：本研究对2019年1月至2021年6月期间在马拉加基隆健康医院收治的121例患者进行了回顾性观察分析。通过生物电阻抗分析（BIA）测量PhA，并使用握力计评估HGS。营养状况通过主观全面评估（SGA）和全球营养不良领导倡议（GLIM）标准进行评估。主要结局指标为12个月死亡率，采用ROC曲线、Kaplan-Meier生存估计和多因素逻辑回归模型进行分析。 结果：较低的PhA（女性<3.8°，男性<5.4°）和较低的HGS（女性<17 kg，男性<28 kg）与较高的12个月死亡率显著相关（p<0.001）。最佳PhA临界值显示出较高的敏感性（85.5%）和特异性（62.2%）。多因素分析证实PhA是死亡率的独立预测因子（OR=0.417，p=0.023）。PhA和HGS值较低的患者生存率降低，强调了这些标志物在临床实践中的重要性。 结论：PhA和HGS是评估血液系统恶性肿瘤患者预后的可靠、无创工具。将这些标志物纳入常规护理可改善风险分层，指导营养干预，并提升患者预后。
肿瘤(癌症)患者之家