文章：

老年与虚弱患者中的弥漫性大B细胞淋巴瘤

Diffuse Large B-Cell Lymphoma in the Older and Frail Patient

原文发布日期：5 March 2025

DOI: 10.3390/cancers17050885

类型: Article

开放获取: 是

英文摘要：

Outcomes in older, unfit, and frail patients with diffuse large B-cell lymphoma (DLBCL) are inferior compared to younger and fit patients. Despite tremendous progress in the treatment landscape of DLBCL, few clinical trials have focused specifically on this high-risk patient population. This review focuses on the pathophysiology unique to the older patient with DLBCL, as well as the evidence behind current treatment approaches. This article also aims to highlight emerging prognostic tools and novel treatment strategies that may improve the outcomes in this patient cohort in the future.

摘要翻译： 

与年轻且身体状况良好的患者相比，老年、体能状态不佳及虚弱弥漫性大B细胞淋巴瘤（DLBCL）患者的预后较差。尽管DLBCL的治疗领域已取得巨大进展，但专门针对这一高危患者群体的临床试验仍较为有限。本综述重点探讨老年DLBCL患者特有的病理生理学特征，以及当前治疗策略背后的循证依据。同时，本文旨在重点介绍新兴的预后评估工具和创新治疗方案，这些进展有望在未来改善此类患者的临床结局。

原文链接：

Diffuse Large B-Cell Lymphoma in the Older and Frail Patient