Background/Objectives: UBC demonstrates a relatively low prevalence in patients under 50 years old. Our study aimed to compare the pathological characteristics of UBC in young and elderly patients and to assess the age-related variations in these characteristics. Methods: This retrospective study from January 2018 to December 2022 encompassed 762 patients with an initial diagnosis of UBC. To evaluate the pathological characteristics of UBC in young patients, compared to elderly patients, we divided our cohort using a cut-off age of 50 years. Additionally, to evaluate the age-dependent variations in these characteristics, we further stratified our patients into three age groups (≤50, 51–70, and >70 years old). Results: Of the 762 patients included in our study, 37 (4.86%) were young (≤50 years old), with a median age of 44 and a M:F ratio of 3.11:1. Conventional UC was the most common histology (86.5%). Regarding tumour grade, we noticed a higher prevalence of PUNLMP (10.8% versus 2.3%) and LGPUC (45.9% versus 37.1%) and a lower prevalence of HGPUC (43.2% versus 60%) and CIS (0% versus 0.6%) in young patients (p= 0.008). In this group, the pTa stage revealed a higher prevalence (64.9% versus 46.8%), while pT1 and pT2 showed a lower prevalence (32.1% versus 18.9% and 20.6% versus 16.2%) (p= 0.179). All results remained consistent when the cohort was stratified into three age groups, showing age-related variations (p= 0.001 andp= 0.089, respectively). Conclusions: In young patients, UBC tends to be of a lower grade and stage compared to elderly patients, and these characteristics demonstrate a gradual age-related stratification.
背景/目的：尿路上皮膀胱癌（UBC）在50岁以下患者中的发病率相对较低。本研究旨在比较年轻与老年UBC患者的病理特征，并评估这些特征随年龄的变化趋势。方法：这项回顾性研究纳入了2018年1月至2022年12月期间首次诊断为UBC的762例患者。为评估年轻患者（与老年患者相比）的UBC病理特征，我们以50岁为界对队列进行分组。此外，为评估这些特征的年龄依赖性变化，我们进一步将患者分为三个年龄组（≤50岁、51-70岁和>70岁）。结果：在纳入研究的762例患者中，37例（4.86%）为年轻患者（≤50岁），中位年龄44岁，男女比例为3.11:1。传统尿路上皮癌是最常见的组织学类型（86.5%）。在肿瘤分级方面，我们发现年轻患者中低度恶性潜能的乳头状尿路上皮肿瘤（10.8%对2.3%）和低级别尿路上皮癌（45.9%对37.1%）的占比更高，而高级别尿路上皮癌（43.2%对60%）和原位癌（0%对0.6%）的占比更低（p=0.008）。在该组中，pTa分期占比更高（64.9%对46.8%），而pT1和pT2分期占比更低（32.1%对18.9%和20.6%对16.2%）（p=0.179）。当队列按三个年龄组分层时，所有结果保持一致，显示出与年龄相关的渐进性变化趋势（p值分别为0.001和0.089）。结论：与老年患者相比，年轻患者的UBC往往分级和分期更低，且这些特征呈现出随年龄增长而逐渐分层的趋势。
肿瘤(癌症)患者之家