文章：

降低前列腺癌风险：频繁射精相关机制的作用

Reduction of Prostate Cancer Risk: Role of Frequent Ejaculation-Associated Mechanisms

原文发布日期：28 February 2025

DOI: 10.3390/cancers17050843

类型: Article

开放获取: 是

英文摘要：

Prostate cancer (PCa) accounts for roughly 15% of diagnosed cancers among men, with disease incidence increasing worldwide. Age, family history and ethnicity, diet, physical activity, and chemoprevention all play a role in reducing PCa risk. The prostate is an exocrine gland that is characterized by its multi-functionality, being involved in reproductive aspects such as male ejaculation and orgasmic ecstasy, as well as playing key roles in the regulation of local and systemic concentrations of 5α-dihydrotestosterone. The increase in androgen receptors at the ventral prostate is the first elevated response induced by copulation. The regulation of prostate growth and function is mediated by an androgen-dependent mechanism. Binding 5-DHT to androgen receptors (AR) results in the formation of a 5α-DHT:AR complex. The interaction of the 5α-DHT:AR complex with the specific DNA enhancer element of androgen-regulated genes leads to the regulation of androgen-specific target genes to maintain prostate homeostasis. Consequently, ejaculation may play a significant role in the reduction of PCa risk. Thus, frequent ejaculation in the absence of risky sexual behavior is a possible approach for the prevention of PCa. In this review, we provide an insight into possible mechanisms regulating the impact of frequent ejaculation on reducing PCa risk.

摘要翻译： 

前列腺癌约占男性确诊癌症的15%，全球发病率呈上升趋势。年龄、家族史与种族、饮食、体力活动及化学预防等因素均对降低前列腺癌风险具有影响。前列腺作为外分泌腺具有多功能特性，既参与男性射精与性高潮等生殖功能，又在局部及全身5α-双氢睾酮浓度调控中发挥关键作用。腹侧前列腺雄激素受体的增加是交配诱导的首个增强反应。前列腺生长与功能的调节通过雄激素依赖机制实现。5α-双氢睾酮与雄激素受体结合形成5α-双氢睾酮-雄激素受体复合物，该复合物与雄激素调控基因的特异性DNA增强子元件相互作用，进而调控雄激素特异性靶基因以维持前列腺稳态。因此，射精行为可能在降低前列腺癌风险方面具有重要作用。在规避高危性行为的前提下，规律射精可作为预防前列腺癌的潜在策略。本综述旨在深入探讨规律射精降低前列腺癌风险的可能调控机制。

原文链接：

Reduction of Prostate Cancer Risk: Role of Frequent Ejaculation-Associated Mechanisms