Mesenchymal stem cells (MSCs) are specialized cells that can differentiate into various types of cells. MSCs can be utilized to treat cancer. However, a MSC is considered a double-edged sword, because it can promote tumor progression and support cancer cell growth. Likewise, MSC-derived exosomes (MSC-Exos) carry various intracellular materials and transfer them to other cells. MSC-Exos could also cause tumor progression, including brain cancer, breast cancer, hepatic cancer, lung cancer, and colorectal cancer, and develop resistance against therapies, mainly chemotherapy, radiotherapy, and immunotherapy. An MSC-Exo promotes tumor development and causes drug resistance in various cancer types. The mechanisms involved in cancer drug resistance vary depending on the cancer cell heterogeneity and complexity. In this article, we have explained the various biomarkers and mechanisms involved in the tumor and resistance development through MSC-Exos in different cancer types.
间充质干细胞（MSCs）是一类能够分化为多种细胞类型的特殊细胞，可用于癌症治疗。然而，间充质干细胞被视为一把双刃剑，因其既能促进肿瘤进展，又能支持癌细胞生长。同样，间充质干细胞来源的外泌体（MSC-Exos）携带多种细胞内物质并将其转移至其他细胞。MSC-Exos也可能导致肿瘤进展（包括脑癌、乳腺癌、肝癌、肺癌和结直肠癌），并引发对化疗、放疗及免疫治疗等主要治疗手段的耐药性。MSC-Exos通过促进肿瘤发展在不同癌症类型中引发耐药现象，其耐药机制因癌细胞的异质性和复杂性而存在差异。本文系统阐述了MSC-Exos在不同癌症类型中促进肿瘤发生和耐药性形成的多种生物标志物及其作用机制。
Mesenchymal Stem Cell-Derived Exosomes in Cancer Resistance Against Therapeutics
肿瘤(癌症)患者之家