Background/Objectives: Male breast cancer (MBC) is a rare malignancy with a globally rising incidence. Due to the paucity of specific evidence, therapeutic strategies are often extrapolated from female breast cancer guidelines. The quality of life (QoL) among MBC patients remains underexplored.Methods: This single-institution retrospective study analyzed male patients who underwent surgery for newly diagnosed breast cancer at our institution from 1998 to 2020. The primary aim was to assess QoL after surgical and medical treatments using a newly developed 12-item dedicated questionnaire. Clinicopathological features were recorded, and oncological and survival outcomes were evaluated, with a specific focus on identifying factors influencing QoL.Results: A total of 109 consecutive MBC patients who underwent surgery were included, with 96.3% undergoing total mastectomy. The median global QoL score was 28.5 out of 36, where scores above 24 indicated a low impact of BC treatments on QoL. Multivariate analyses identified adjuvant chemotherapy (p< 0.001) and postoperative complications (p< 0.001) as significant predictors of poorer QoL. Patients reported significantly lower scores on medical treatment-related items compared to surgery-related items (p< 0.001). The 10-year overall survival rate was 79.1%, with a 10-year BC-specific mortality of 3.5%. Advanced age, higher stage disease, and receiving adjuvant chemotherapy were independently associated with poorer overall survival.Conclusions: Despite elevated mastectomy rates, MBC patients self-reported high levels of satisfaction with their treatment outcomes. Medical therapies showed a more pronounced negative impact on QoL than surgery. These findings provide novel insights into the QoL of MBC patients, highlighting the need for future prospective studies and tailored treatments.
**背景/目的：** 男性乳腺癌是一种罕见的恶性肿瘤，其全球发病率呈上升趋势。由于缺乏特异性证据，其治疗策略常借鉴女性乳腺癌指南。男性乳腺癌患者的生活质量仍待深入研究。 **方法：** 本研究为单中心回顾性分析，纳入了1998年至2020年间在我院接受手术的新诊断男性乳腺癌患者。主要目的是使用新开发的12项专用问卷，评估手术及药物治疗后的生活质量。记录临床病理特征，评估肿瘤学及生存结局，并特别关注影响生活质量的因素。 **结果：** 共纳入109例连续接受手术的男性乳腺癌患者，其中96.3%接受了全乳房切除术。生活质量总体评分中位数为28.5分（总分36分），评分高于24分表明乳腺癌治疗对生活质量影响较小。多变量分析确定辅助化疗（p < 0.001）和术后并发症（p < 0.001）是生活质量较差的显著预测因素。与手术相关项目相比，患者报告的治疗相关项目评分显著更低（p < 0.001）。10年总生存率为79.1%，10年乳腺癌特异性死亡率为3.5%。高龄、更高分期以及接受辅助化疗与较差的总生存期独立相关。 **结论：** 尽管乳房切除术比例较高，但男性乳腺癌患者自我报告对其治疗结果满意度高。与手术相比，药物治疗对生活质量的负面影响更为显著。这些发现为男性乳腺癌患者的生活质量提供了新的见解，强调了未来开展前瞻性研究和制定个体化治疗的必要性。
肿瘤(癌症)患者之家