Introduction: The emergence of cancer immunotherapy has revolutionized cancer treatment, offering remarkable outcomes for patients across various malignancies. However, the heterogeneous response to immunotherapy underscores the necessity of understanding additional factors influencing treatment efficacy. Among these factors, the human microbiota has garnered significant attention for its potential role in modulating immune response. Body: This review explores the intricate relationship between the human microbiota and cancer immunotherapy, highlighting recent advances and potential mechanisms underlying microbial influence on treatment outcomes. Conclusion: Insights into the microbiome’s impact on immunotherapy response not only deepen our understanding of cancer pathogenesis but also hold promise for personalized therapeutic strategies aimed at optimizing patient outcomes.
引言：癌症免疫疗法的出现彻底改变了癌症治疗模式，为多种恶性肿瘤患者带来了显著疗效。然而，免疫治疗反应的异质性凸显了理解影响治疗效果其他因素的必要性。在诸多因素中，人体微生物群因其在调节免疫反应中的潜在作用而备受关注。主体：本综述探讨人体微生物群与癌症免疫疗法之间的复杂关联，重点阐述微生物影响治疗结局的最新研究进展及其潜在作用机制。结论：对微生物群如何影响免疫治疗反应的深入理解，不仅深化了我们对癌症发病机制的认识，更为优化患者预后的个体化治疗策略提供了新的可能。
Unlocking the Microbial Symphony: The Interplay of Human Microbiota in Cancer Immunotherapy Response
肿瘤(癌症)患者之家