文章：

智力障碍女性卵巢癌：现有数据研究

Ovarian Cancer in Women with Intellectual Disability: Current Data

原文发布日期：26 February 2025

DOI: 10.3390/cancers17050805

类型: Article

开放获取: 是

英文摘要：

Objective: We evaluate ovarian cancer (OC) in women with intellectual disability (ID). Methods: We reviewed the literature and added personal observations. The literature search included data from epidemiological studies on cancer incidence and mortality, institutional experiences, and case reports. We also used data from the Hérault Tumor Registry (HTR) in southern France. Results: A total of 72 articles met the inclusion criteria, which included 41 cases of OC. The review yielded 29 (74%) germ cell tumors, mainly in girls and young women, and only 4 (10%) ovarian carcinomas, all in adult women. In contrast, the HTR contained six cases of OC and one borderline tumor in adult women with ID aged > 45 years, but no cancer in children and adolescents with ID. These OC cases in adults were discovered at an advanced stage. We found that symptoms revealing OC in women with ID do not differ from those in the general population. However, diagnosis is more complicated in women with ID because they do not communicate easily and may express pain and unease in an unusual way, often through behavioral changes. Conclusion: OC could be as frequent in women with ID as in the general population and discovered at a late stage. The literature review indicates that girls and adolescents with ID develop mainly germ cell OC, and few carcinomas have been reported in women with ID. In contrast, the HTR was similar to the general population, with carcinomas in women with ID and no OC in children with ID.

摘要翻译： 

目的：本研究旨在评估智力障碍（ID）女性中的卵巢癌（OC）情况。方法：我们回顾了相关文献并结合个人观察。文献检索涵盖了癌症发病率和死亡率的流行病学研究数据、机构经验以及病例报告。同时，我们还使用了法国南部埃罗省肿瘤登记处（HTR）的数据。结果：共有72篇文章符合纳入标准，其中包括41例OC病例。文献回顾显示，其中29例（74%）为生殖细胞肿瘤，主要见于女孩和年轻女性；仅有4例（10%）为卵巢癌，均发生于成年女性。相比之下，HTR数据显示，在45岁以上的智力障碍成年女性中，有6例OC病例和1例交界性肿瘤，但在智力障碍儿童和青少年中未发现癌症病例。这些成年智力障碍女性的OC病例均发现于晚期阶段。我们发现，智力障碍女性中OC的症状与一般人群并无差异。然而，由于智力障碍女性沟通困难，且可能通过行为改变等非典型方式表达疼痛和不适，其诊断更为复杂。结论：智力障碍女性中OC的发病率可能与一般人群相当，但往往发现较晚。文献回顾表明，智力障碍女孩和青少年主要发生生殖细胞OC，而智力障碍女性中报道的卵巢癌病例较少。相比之下，HTR数据与一般人群相似，即智力障碍女性中可见卵巢癌，而智力障碍儿童中未发现OC病例。

原文链接：

Ovarian Cancer in Women with Intellectual Disability: Current Data