文章：

KIF11与KIF14是子宫内膜样腺癌患者的新型潜在预后生物标志物

KIF11 and KIF14 Are a Novel Potential Prognostic Biomarker in Patients with Endometrioid Carcinoma

原文发布日期：26 February 2025

DOI: 10.3390/cancers17050804

类型: Article

开放获取: 是

英文摘要：

BackgroundThe current study aimed to evaluate the function of KIF11 and KIF14 in endometroid cancer and assess their role as a prognostic biomarker and therapeutic target for treating endometroid cancer.MethodsTherefore, we immunohistochemically tested KIF11 and KIF14 proteins in tumoral and non-tumoral tissue sections fromn= 92 endometroid cancer patients with respect to major prognostic and predictive characteristics, as well as treatment outcome.ResultsWe found that KIF11 protein levels were higher in tumor tissues as compared to normal tissues, whereas KIF14 protein levels were lower in cancer tissue. High KIF11 protein levels and low KIF14 protein levels were independent prognostic factors for poor OS. Furthermore, the expression profile of KIF11highKIF14low was associated with the worst OS, and it was superior to each single protein alone in predicting patient prognosis.ConclusionsIn summary, individual and combined expression of KIF11 and KIF14 proteins may serve as potential prognostic biomarkers for endometroid cancer.

摘要翻译： 

背景：本研究旨在评估KIF11和KIF14在子宫内膜样癌中的功能，并探讨其作为子宫内膜样癌预后生物标志物及治疗靶点的潜力。 方法：我们采用免疫组织化学方法检测了92例子宫内膜样癌患者的肿瘤组织与非肿瘤组织中KIF11和KIF14蛋白的表达情况，并结合主要预后指标、预测特征及治疗结果进行分析。 结果：研究发现，与正常组织相比，肿瘤组织中KIF11蛋白水平升高，而KIF14蛋白水平降低。高KIF11蛋白水平和低KIF14蛋白水平均是总体生存率不良的独立预后因素。此外，KIF11高表达/KIF14低表达的蛋白表达模式与最差的总体生存率相关，且在预测患者预后方面优于单一蛋白指标。 结论：综上所述，KIF11和KIF14蛋白的单独及联合表达可能作为子宫内膜样癌潜在的预后生物标志物。

原文链接：

KIF11 and KIF14 Are a Novel Potential Prognostic Biomarker in Patients with Endometrioid Carcinoma