文章：

癌症诊断与握力对欧洲中老年人抑郁的个体及联合影响研究

Individual and Joint Associations of Cancer Diagnosis and Handgrip Strength with Depression in European Middle-Aged and Older Adults

原文发布日期：23 February 2025

DOI: 10.3390/cancers17050754

类型: Article

开放获取: 是

英文摘要：

Background/Objectives:Depression is influenced by a multitude of interconnected factors, including cancer and handgrip strength. The purpose of our study is to examine how handgrip strength and cancer diagnosis are individually and jointly associated with depression.Methods:An observational study was employed using secondary data from the Survey of Health, Aging, and Retirement in Europe waves 7 and 8. The sample comprised 7 641 participants (71.1 ± 7.7 years), from 12 European countries.Results:Having a cancer diagnosis was associated with greater odds of depression (depression 2017 model: OR = 1.35, 95% CI = 1.03, 1.75; depression 2019 model: OR = 1.48, 95% CI = 1.12, 1.95). Being in a higher handgrip tertile was associated with lower odds of depression (depression 2017 model: tertile 2, OR = 0.65, 95% CI = 0.56, 0.74 and tertile 3, OR = 0.56, 95% CI = 0.49, 0.65; depression 2019 model: tertile 2, OR = 0.74, 95% CI = 0.64, 0.86 and tertile 3, OR = 0.76, 95% CI = 0.65, 0.88). The greatest reduction in odds for depression was found for participants without cancer and in the third handgrip strength tertile (depression 2017: OR = 0.42, 95% CI = 0.29, 0.61; depression 2019: OR = 0.40, 95% CI = 0.28, 0.58).Conclusions:Both cancer and handgrip strength were associated with depression, with the first increasing its risk and the latter reducing it. Individuals without cancer and in the highest tertile of handgrip strength have lower odds of depression in both analyses.

摘要翻译： 

背景/目的：抑郁症受多种相互关联的因素影响，包括癌症和握力。本研究旨在探讨握力与癌症诊断如何分别及共同与抑郁症相关联。 方法：本研究采用观察性设计，利用欧洲健康、老龄化与退休调查第七和第八轮数据的二次分析。样本涵盖来自12个欧洲国家的7,641名参与者（年龄71.1±7.7岁）。 结果：癌症诊断与较高的抑郁症风险相关（2017年抑郁症模型：OR=1.35，95% CI=1.03-1.75；2019年抑郁症模型：OR=1.48，95% CI=1.12-1.95）。较高的握力水平与较低的抑郁症风险相关（2017年抑郁症模型：第二三分位组OR=0.65，95% CI=0.56-0.74；第三三分位组OR=0.56，95% CI=0.49-0.65；2019年抑郁症模型：第二三分位组OR=0.74，95% CI=0.64-0.86；第三三分位组OR=0.76，95% CI=0.65-0.88）。在无癌症诊断且处于握力第三三分位组的参与者中观察到抑郁症风险最大程度的降低（2017年模型：OR=0.42，95% CI=0.29-0.61；2019年模型：OR=0.40，95% CI=0.28-0.58）。 结论：癌症与握力均与抑郁症显著相关，前者增加抑郁风险，后者降低抑郁风险。两项分析均显示，无癌症诊断且握力处于最高三分位组的个体具有更低的抑郁症发生风险。

原文链接：

Individual and Joint Associations of Cancer Diagnosis and Handgrip Strength with Depression in European Middle-Aged and Older Adults