文章：

根据内镜分型与治疗方式探讨结直肠黏膜相关淋巴组织淋巴瘤的临床特征与长期预后：一项多中心研究

Clinical Characteristics and Long-Term Prognosis of Colorectal Mucosa-Associated Lymphoid Tissue Lymphoma According to the Endoscopic Classification and Treatment Modality: A Multicenter Study

原文发布日期：22 February 2025

DOI: 10.3390/cancers17050750

类型: Article

开放获取: 是

英文摘要：

Background/Objectives: The clinical characteristics of colorectal mucosa-associated lymphoid tissue (MALT) lymphoma remain poorly defined, and there is no standardized treatment for the disease. Therefore, we investigated the clinical characteristics of colorectal MALT lymphoma and its prognosis based on different treatment modalities.Methods: A retrospective analysis was performed on patients diagnosed with colorectal MALT lymphoma from 2003 to 2021 across six hospitals in Korea’s Busan–Ulsan–Gyeongnam area. Macroscopic findings classified all cases into polyposis type, mass-forming type, subepithelial lesion type, and inflammatory type.Results: Fifty-one patients were enrolled. The median age was 59 years, and 27 patients (52.9%) were male. Five patients (9.8%) were stage IV at initial diagnosis. As for the endoscopic type, the polyposis type was the most common (39.2%). There was no statistically significant difference in disease progression according to the endoscopic type (p= 0.813). Three cases of disease progression were confirmed in stage I after treatment, and one of them died due to disease progression. No disease progression was identified in other stages. According to the treatment modality, disease progression was identified in 1 of 16 patients who underwent endoscopic resection and 2 of 16 patients who underwent chemotherapy. There was no disease progression in the observation group. However, there was no statistically significant difference in disease progression according to treatment modality (p= 0.889).Conclusions: Colorectal MALT lymphoma showed good prognosis regardless of the initial stage, endoscopic type, or treatment modality.

摘要翻译： 

背景/目的：结直肠黏膜相关淋巴组织（MALT）淋巴瘤的临床特征尚不明确，且目前缺乏针对该疾病的标准治疗方案。因此，本研究旨在探讨结直肠MALT淋巴瘤的临床特征，并基于不同治疗方式评估其预后情况。 方法：本研究对2003年至2021年间在韩国釜山-蔚山-庆南地区六家医院诊断为结直肠MALT淋巴瘤的患者进行了回顾性分析。根据内镜下宏观表现，将所有病例分为息肉型、肿块型、上皮下病变型和炎症型。 结果：共纳入51例患者。中位年龄为59岁，其中男性27例（52.9%）。初诊时为IV期的患者有5例（9.8%）。内镜下分型以息肉型最为常见（39.2%）。不同内镜分型间的疾病进展无统计学显著差异（p=0.813）。I期患者治疗后出现3例疾病进展，其中1例因疾病进展死亡。其他分期患者均未出现疾病进展。按治疗方式分析，接受内镜切除术的16例患者中有1例出现疾病进展，接受化疗的16例患者中有2例出现疾病进展。观察组未出现疾病进展。然而，不同治疗方式间的疾病进展率无统计学显著差异（p=0.889）。 结论：结直肠MALT淋巴瘤无论初诊分期、内镜分型或治疗方式如何，均表现出良好的预后。

原文链接：

Clinical Characteristics and Long-Term Prognosis of Colorectal Mucosa-Associated Lymphoid Tissue Lymphoma According to the Endoscopic Classification and Treatment Modality: A Multicenter Study