文章：

墨西哥儿童早期感染发生率与急性白血病发病风险研究

Early Infection Incidence and Risk of Acute Leukemia Development Among Mexican Children

原文发布日期：21 February 2025

DOI: 10.3390/cancers17050733

类型: Article

开放获取: 是

英文摘要：

Background: The few epidemiologic studies of infection exposure in early life and acute leukemia (AL) risk in Latino children have yielded inconsistent results, suggesting a possible effect of ethnicity. Here, we examined the correlation between infection exposure and acute leukemia risk in children from Mexico City—One of the biggest Latino cities worldwide. Methods: This study included 1455 Mexican children diagnosed with de novo AL (2002–2016), and 1455 control individuals frequency-matched by age and health institution. The AL population included acute lymphoblastic leukemia (ALL), Pre-B ALL, and acute myeloblastic leukemia (AML). Logistic regression analyses were performed to investigate direct and indirect proxies of infection in children or their mothers. Results: Upper respiratory tract infections during the child’s first year of life were a risk factor for AL (OR, 2.76; 95% CI, 1.48–5.15), including ALL (OR, 3.14; 95% CI, 1.67–5.89) and Pre-B (OR, 3.11; 95% CI, 1.63–5.96). Mother’s infections before and during pregnancy were protective factors against AL (OR, 0.55; 95% CI, 0.47–0.64; and OR, 0.61; 95% CI, 0.52–0.72, respectively). These associations included ALL and Pre-B. In contrast, only mothers’ infections before pregnancy and respiratory tract infections were protective factors against AML (OR, 0.45; 95% CI, 0.33–0.62; and OR, 0.50; 95% CI, 0.37–0.68, respectively). Conclusions: Infections during the first year of life were associated with AL development in children of Mexico City. Additionally, mothers’ exposure to respiratory tract infections before and during pregnancy reduced the AL risk in this Latino population.

摘要翻译： 

背景：关于拉丁裔儿童早期感染暴露与急性白血病（AL）风险的流行病学研究数量有限，且结果存在不一致，提示可能存在种族因素的影响。本研究旨在探讨全球最大的拉丁裔城市之一——墨西哥城儿童感染暴露与急性白血病风险之间的相关性。方法：本研究纳入2002年至2016年间诊断为原发急性白血病的1455名墨西哥儿童，以及按年龄和医疗机构进行频数匹配的1455名对照个体。急性白血病病例包括急性淋巴细胞白血病（ALL）、前体B细胞急性淋巴细胞白血病（Pre-B ALL）和急性髓系白血病（AML）。采用逻辑回归分析评估儿童或其母亲感染暴露的直接与间接指标。结果：儿童出生后第一年内发生的上呼吸道感染是急性白血病的危险因素（OR=2.76，95% CI：1.48-5.15），该关联在ALL（OR=3.14，95% CI：1.67-5.89）和Pre-B ALL（OR=3.11，95% CI：1.63-5.96）中均显著。母亲孕前（OR=0.55，95% CI：0.47-0.64）和孕期感染（OR=0.61，95% CI：0.52-0.72）则是急性白血病的保护因素，此关联同样存在于ALL和Pre-B ALL亚型。而对于AML，仅母亲孕前感染（OR=0.45，95% CI：0.33-0.62）和呼吸道感染（OR=0.50，95% CI：0.37-0.68）显示保护作用。结论：墨西哥城儿童出生后第一年的感染暴露与其急性白血病发生风险相关。此外，母亲在孕前及孕期经历呼吸道感染可降低该拉丁裔人群的急性白血病风险。

原文链接：

Early Infection Incidence and Risk of Acute Leukemia Development Among Mexican Children