Introduction: Venous thromboembolism (VTE) is a major cause of non-cancer-related mortality in cancer patients. Understanding how demographic factors and cancer types influence VTE risk is critical for developing prevention strategies. This study investigates the incidence of VTE in a large cancer patient population, focusing on gender, race, and differences between solid and hematological malignancies. Methods: Data from the National Inpatient Sample (NIS) database were used to identify cancer patients diagnosed with acute VTE. The patients were divided into those with solid and hematological cancers. Key demographic and clinical characteristics were collected, and patients were matched 1:1 using propensity scoring. Statistical analyses, including logistic regression, assessed VTE incidence and its associations with demographic and cancer type variables. Ap-value of <0.05 indicated statistical significance. Results: Out of 1,233,832 cancer patients, 63,505 (5.1%) were diagnosed with acute VTE. Females had a higher VTE rate than males (5.5% vs. 4.8%,p< 0.001). Racial disparities showed Black patients with the highest incidence (6.4%), followed by White patients (5%). Patients with solid malignancies exhibited a significantly higher incidence of VTE compared to those with hematological malignancies (5.4% vs. 4.1%;p< 0.001), with lung cancer and non-Hodgkin lymphoma mostly associated with VTE. Conclusions: This study identifies demographic and cancer-specific differences in VTE risk, emphasizing the need for personalized prevention. High-risk groups, including those with solid tumors, females, and Black patients, may benefit from targeted strategies to reduce the burden of VTE and improve cancer outcomes.
引言：静脉血栓栓塞症（VTE）是癌症患者非癌症相关死亡的主要原因。了解人口统计学因素和癌症类型如何影响VTE风险对于制定预防策略至关重要。本研究调查了大规模癌症患者群体中VTE的发病率，重点关注性别、种族以及实体瘤与血液系统恶性肿瘤之间的差异。方法：利用美国国家住院患者样本数据库的数据，识别诊断为急性VTE的癌症患者。患者被分为实体瘤和血液系统恶性肿瘤两组。收集关键人口统计学和临床特征，并采用倾向性评分进行1:1匹配。通过逻辑回归等统计分析评估VTE发病率及其与人口统计学和癌症类型变量的关联，p值<0.05表示具有统计学意义。结果：在1,233,832名癌症患者中，63,505人（5.1%）被诊断为急性VTE。女性VTE发生率高于男性（5.5% vs. 4.8%，p<0.001）。种族差异显示，黑人患者发病率最高（6.4%），其次是白人患者（5%）。实体瘤患者的VTE发生率显著高于血液系统恶性肿瘤患者（5.4% vs. 4.1%；p<0.001），其中肺癌和非霍奇金淋巴瘤与VTE关联最为密切。结论：本研究揭示了VTE风险在人口统计学和癌症类型方面的差异，强调了个性化预防的必要性。高危人群，包括实体瘤患者、女性和黑人患者，可能受益于针对性策略，以减轻VTE负担并改善癌症预后。
肿瘤(癌症)患者之家