Background/Objective:Smoking is an individual risk factor for bladder cancer. Many patients are still smoking at the time of their diagnosis, yet few trials have examined smoking cessation interventions (SCIs) in relation to transurethral resection of the bladder tumor (TURBT). This study therefore aimed to compare the efficacy of a hospital-based 6-week intensive SCI with standard treatment among this patient group.Methods:A parallel-arm randomized controlled trial was conducted from December 2021 to March 2024 at two university hospital urology departments in Denmark. A total of 38 daily smokers undergoing TURBT were allocated to the hospital-based intensive SCI, including weekly meetings, patient education, motivational support, and complimentary nicotine replacement therapy or the standard treatment with very brief advice and referral to the same intensive SCI at a municipality clinic. The primary outcome was smoking cessation at the end of the intervention, assessed through participant interviews. The secondary outcomes included continuous abstinence at three and six months, quality of life, and frailty. Analyses were performed as intention-to-treat.Results:After six weeks, 37% in the hospital-based group and 6% in the standard group achieved smoking cessation (p= 0.042). At three and six months the quit rates were, 37% and 26% in the hospital-based group, compared to 0% and 0% in the standard group, respectively. No significant differences in quality of life or frailty were found.Conclusions:This trial found that hospital-based intensive SCI increased cessation rates compared to standard treatment. It would be valuable to evaluate the impact on postoperative complications, cancer prognosis, and long-term cessation in a sizeable new study.
背景/目的：吸烟是膀胱癌的个体危险因素。许多患者在确诊时仍在吸烟，但针对经尿道膀胱肿瘤切除术（TURBT）患者开展戒烟干预（SCI）的研究甚少。本研究旨在比较该患者群体中，为期6周的医院强化戒烟干预与标准治疗的效果差异。 方法：2021年12月至2024年3月，在丹麦两所大学医院的泌尿外科开展了一项平行组随机对照试验。共纳入38名接受TURBT的每日吸烟者，随机分配至医院强化戒烟干预组（包括每周会谈、患者教育、动机性支持和免费尼古丁替代疗法）或标准治疗组（接受极简短建议并转诊至市政诊所接受相同强化干预）。主要结局指标为干预结束时的戒烟率，通过参与者访谈评估。次要结局包括三个月及六个月的持续戒断率、生活质量及衰弱程度。数据分析采用意向性治疗原则。 结果：干预六周后，医院干预组戒烟率为37%，标准治疗组为6%（p=0.042）。在三个月和六个月时，医院干预组戒烟率分别为37%和26%，而标准治疗组均为0%。两组在生活质量及衰弱程度方面未见显著差异。 结论：本研究表明，与标准治疗相比，医院强化戒烟干预能显著提高戒烟率。未来有必要通过大规模研究进一步评估该干预对术后并发症、癌症预后及长期戒烟效果的影响。
肿瘤(癌症)患者之家