Background/Objectives: Non-Hodgkin lymphoma (NHL) represents 63% of all hematological malignancies in France, with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) being the two most frequent forms. With the improvement of therapeutics, the issue of health-related quality of life (HRQoL) is becoming increasingly crucial for these patients. The aim was to compare HRQoL of NHL survivors with that of the general French population and to identify factors associated with HRQoL in NHL survivors.Methods: We conducted a population-based study among living patients from three registries of hematological malignancies, using standardized questionnaires, including the SF-12, in September 2023. The data collected were compared to those of a normative general French cohort.Results: In total, 493 patients completed the study questionnaires, yielding a response rate of 36%. The median time since diagnosis was 8 years (IQR 6–10) These NHL survivors reported lower HRQoL compared to the general French population, except in terms of bodily pain (p< 0.01). Each one-year increase in the time since diagnosis was associated with an increase in social functioning (p= 0.009). Men had better general health (p= 0.01) and less bodily pain (p= 0.007) than women. Higher income was associated with better HRQoL (p< 0.01). Underweight or obesity were associated with poorer physical functioning (p= 0.008). The presence of comorbidities, socioeconomic deprivation, anxiety, and depression were associated with poorer HRQoL (p< 0.01).Conclusions: This study provides valuable information of HRQoL values for comparison in further follow-up studies and proposes measures that could be implemented to improve the HRQoL of NHL survivors.
背景/目的：在法国，非霍奇金淋巴瘤（NHL）占所有血液系统恶性肿瘤的63%，其中弥漫性大B细胞淋巴瘤（DLBCL）和滤泡性淋巴瘤（FL）是最常见的两种亚型。随着治疗手段的进步，健康相关生活质量（HRQoL）问题对这些患者而言日益重要。本研究旨在比较NHL幸存者与法国普通人群的HRQoL，并识别与NHL幸存者HRQoL相关的因素。 方法：我们于2023年9月，基于三个血液系统恶性肿瘤登记库中的存活患者开展了一项人群研究，使用了包括SF-12在内的标准化问卷。收集的数据与法国普通人群的常模队列进行了比较。 结果：共有493名患者完成了研究问卷，应答率为36%。自诊断以来的中位时间为8年（四分位距6-10年）。与法国普通人群相比，这些NHL幸存者报告的HRQoL较低，但在身体疼痛方面除外（p < 0.01）。诊断后每增加一年，社会功能随之改善（p = 0.009）。男性在总体健康状况（p = 0.01）和身体疼痛（p = 0.007）方面优于女性。较高收入与更好的HRQoL相关（p < 0.01）。体重过轻或肥胖与较差的躯体功能相关（p = 0.008）。合并症的存在、社会经济剥夺、焦虑和抑郁与较差的HRQoL相关（p < 0.01）。 结论：本研究为后续随访比较提供了有价值的HRQoL数据，并提出了可实施的措施以改善NHL幸存者的HRQoL。
肿瘤(癌症)患者之家