文章：

立体定向体部放射治疗（SBRT）用于治疗伴有下腔静脉癌栓的肾细胞癌

Stereotactic Body Radiation Therapy (SBRT) for Renal Cell Carcinoma with Inferior Vena Cava Tumor Thrombus

原文发布日期：19 February 2025

DOI: 10.3390/cancers17040710

类型: Article

开放获取: 是

英文摘要：

The prognosis for untreated renal cell carcinoma (RCC) with inferior vena cava tumor thrombus (IVC TT) is poor, and the only curative treatment option is extirpative surgery. However, radical nephrectomy with IVC thrombectomy is associated with high rates of morbidity and mortality. Historically, RCC was considered radioresistant, but it appears to be sensitive to higher doses per fraction. Stereotactic body radiation therapy (SBRT), which delivers high ablative radiation doses to focal targets, has been shown to be an effective treatment option for both non-metastatic and metastatic RCC. Emerging data also suggest its role in the management of RCC with IVC TT. This article reviews the available evidence on the use of SBRT in RCC patients with IVC TT, considering its application as curative, palliative, and neoadjuvant therapy.

摘要翻译： 

伴有下腔静脉癌栓（IVC TT）的肾细胞癌（RCC）若未经治疗预后较差，根治性手术是目前唯一可能治愈的治疗选择。然而，根治性肾切除术联合下腔静脉癌栓切除术具有较高的并发症发生率和死亡率。传统观点认为肾细胞癌具有放射抵抗性，但研究发现其对大分割剂量放疗较为敏感。立体定向体部放疗（SBRT）能够对局部病灶实施高剂量消融性照射，已被证实是非转移性和转移性肾细胞癌的有效治疗选择。最新研究数据也提示其在伴有下腔静脉癌栓的肾细胞癌治疗中具有潜在价值。本文系统综述了SBRT在伴有下腔静脉癌栓的肾细胞癌患者中作为根治性、姑息性及新辅助治疗的现有循证依据。

原文链接：

Stereotactic Body Radiation Therapy (SBRT) for Renal Cell Carcinoma with Inferior Vena Cava Tumor Thrombus