Background:Music intervention (MI) is a promising complementary therapy for alleviating psychological distress in patients with cancer undergoing radiotherapy. This systematic review and meta-analysis assessed the efficacy of MI in reducing anxiety, depression, and fatigue in these patients.Methods:A comprehensive search was conducted in MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov, and the International Clinical Trials Registry Platform from inception to 9 January 2025. We included randomized controlled trials (RCTs) and cohort studies investigating MI’s impact on psychological outcomes in patients with cancer receiving radiotherapy in this review. The study quality was appraised using the Cochrane Risk of Bias 2.0 for RCTs and the ROBINS-I tool for cohort studies. A meta-analysis was performed using a random-effects model in Review Manager 5.4.Results:A total of 13 studies (11 RCTs and 2 cohort studies) with 1073 participants were included. The pooled analysis revealed a significant reduction in anxiety (mean difference [MD]: −3.53, 95% confidence interval [CI]: −5.98 to −1.07,p= 0.003), a non-significant effect on depression (MD: −1.12, 95% CI: −3.25 to 1.01,p= 0.29), and a significant improvement in fatigue (MD: −15.88, 95% CI: −28.19 to −3.57,p= 0.01). A subgroup analysis based on intervention type indicated that music medicine (MM) was more effective in reducing anxiety compared to music therapy (MT).Conclusions:The findings of this study suggest that MI, particularly MM, may be beneficial in alleviating anxiety and fatigue in patients with cancer undergoing radiotherapy, but its impact on depression remains inconclusive. Future studies should employ standardized methodologies and rigorous RCT designs to validate these findings.
背景：音乐干预是一种有前景的辅助疗法，可用于缓解接受放疗的癌症患者的心理困扰。本系统综述与荟萃分析评估了音乐干预在减轻此类患者焦虑、抑郁和疲劳方面的疗效。 方法：系统检索了从建库至2025年1月9日期间MEDLINE、EMBASE、Cochrane对照试验中心注册库、ClinicalTrials.gov及国际临床试验注册平台中的相关研究。本研究纳入了探讨音乐干预对接受放疗的癌症患者心理结局影响的随机对照试验和队列研究。采用Cochrane偏倚风险评估工具2.0版评估随机对照试验质量，使用ROBINS-I工具评估队列研究质量。在Review Manager 5.4软件中采用随机效应模型进行荟萃分析。 结果：共纳入13项研究（11项随机对照试验和2项队列研究），涉及1073名参与者。汇总分析显示：焦虑显著减轻（均数差：-3.53，95%置信区间：-5.98至-1.07，p=0.003）；对抑郁的影响不显著（均数差：-1.12，95%置信区间：-3.25至1.01，p=0.29）；疲劳症状显著改善（均数差：-15.88，95%置信区间：-28.19至-3.57，p=0.01）。基于干预类型的亚组分析表明，音乐医学在减轻焦虑方面比音乐治疗更具效果。 结论：本研究结果表明，音乐干预（特别是音乐医学）可能有助于缓解接受放疗的癌症患者的焦虑和疲劳症状，但其对抑郁的影响尚无定论。未来研究应采用标准化方法和严谨的随机对照试验设计以验证这些发现。
肿瘤(癌症)患者之家