Background:Advancements in therapeutic approaches and standard medical interventions have significantly improved the prognosis of patients with differentiated thyroid cancer. However, uncertainties remain regarding the optimal timing and protocols for dental implant placement in patients undergoing radioiodine-131 (I-131) therapy. Debates continue about the potential effects of radiation on osseointegration dynamics and implant viability. This in vitro study assessed the impact of radiodiodine-131 (I-131) used for differentiated thyroid cancer on the structure of zirconia and titanium implants.Methods:A total of 60 implants were utilized, with distribution into two cohorts: titanium implants (Ti,n= 30) and zirconia implants (Zr,n= 30). Subsequently, the Ti and Zr implants were immersed in I-131 solution and retrieved at specified time intervals: 0, 6, 12, 24, 48 h, and 8 days post irradiation. The analyses used to characterize the structure of the implants were radioactivity, scanning electron microscopy, atomic force microscopy, roughness, and Vickers hardness assessment.Results:The findings indicate that the zirconia implants exhibited minimal ultra-structural topographic changes after irradiation. Notable topographical changes and debris deposition on zirconia surfaces became evident after 24 h, with cumulative effects observed after 192 h. The titanium implants, on the other hand, showed surface alterations beginning at 12 h of exposure. Significant changes, including erosive patterns and substantial debris deposits, occurred after 48 and 192 h, leading to increased surface roughness by 24 h. Implants exposed for 12 and 24 h formed a statistically significant group, indicating the onset of surface alteration accumulation. The erosion debris confirmed the surface alterations induced by radioiodine-131 exposure.Conclusions:Overall, the Zr implants demonstrated greater stability compared to the Ti implants following radioiodine-131 exposure.
背景：治疗方法和标准医疗干预的进步显著改善了分化型甲状腺癌患者的预后。然而，对于接受放射性碘-131（I-131）治疗的患者，牙种植体植入的最佳时机和方案仍存在不确定性。关于辐射对骨整合动力学和种植体存活率的潜在影响，争议仍在持续。这项体外研究评估了用于分化型甲状腺癌的放射性碘-131（I-131）对氧化锆和钛种植体结构的影响。 方法：共使用60个种植体，分为两组：钛种植体（Ti，n=30）和氧化锆种植体（Zr，n=30）。随后，将Ti和Zr种植体浸入I-131溶液中，并在特定时间点取出：照射后0、6、12、24、48小时和8天。用于表征种植体结构的分析包括放射性测定、扫描电子显微镜、原子力显微镜、粗糙度和维氏硬度评估。 结果：研究结果表明，氧化锆种植体在照射后表现出极微的超微结构形貌变化。氧化锆表面在24小时后出现明显的形貌变化和碎屑沉积，并在192小时后观察到累积效应。相比之下，钛种植体在暴露12小时后开始出现表面改变。在48小时和192小时后发生了显著变化，包括侵蚀模式和大量碎屑沉积，导致表面粗糙度在24小时时增加。暴露12小时和24小时的种植体形成了一个具有统计学显著性的组别，表明表面改变积累的开始。侵蚀碎屑证实了放射性碘-131暴露引起的表面改变。 结论：总体而言，在放射性碘-131暴露后，与钛种植体相比，氧化锆种植体表现出更高的稳定性。
肿瘤(癌症)患者之家