文章：

优化乳房重建效果：激素治疗管理的作用

Optimizing Outcomes in Breast Reconstruction: The Role of Hormonal Therapy Management

原文发布日期：17 February 2025

DOI: 10.3390/cancers17040672

类型: Article

开放获取: 是

英文摘要：

Background: Breast cancer comprises diverse subtypes with prognostic and therapeutic implications. Hormone therapy plays a crucial role in managing tumors expressing hormonal receptors, but its impact on breast reconstruction outcomes remains unclear. This study aims to evaluate the association between perioperative hormone therapy continuation and the incidence of postoperative complications following breast reconstruction (including autologous, prosthetic, and hybrid techniques), with a focus on identifying specific complication types to refine patient management strategies. Methods: A retrospective analysis was conducted on patients who underwent breast reconstruction following mastectomy for hormone receptor-positive breast cancer. Patients were categorized based on the appropriate discontinuation of hormonal therapy. Clinical data, including patient characteristics, treatment regimens, and complication occurrences, were registered and analyzed. Results: Inadequate suspension of hormonal therapy during the perioperative period was significantly associated with a higher rate of complications, particularly in the immediate and early phases. Complications such as skin alterations, flap failure, seroma development, and clinical infection showed significant associations with the continuation of hormone therapy (p< 0.05). No significant differences were observed for other complications. Conclusions: Preliminary findings suggest a potential correlation between the continuation of hormone therapy during the perioperative phase and the development of complications following breast reconstruction.

摘要翻译： 

背景：乳腺癌包含多种亚型，其预后和治疗意义各不相同。激素治疗在管理表达激素受体的肿瘤中起着关键作用，但其对乳房重建结果的影响尚不明确。本研究旨在评估围手术期持续激素治疗与乳房重建术后并发症发生率（包括自体、假体及混合技术）之间的关联，重点关注识别特定并发症类型，以优化患者管理策略。 方法：对因激素受体阳性乳腺癌接受乳房切除术后进行乳房重建的患者进行回顾性分析。根据是否适当停用激素治疗对患者进行分类。记录并分析临床数据，包括患者特征、治疗方案及并发症发生情况。 结果：围手术期激素治疗未充分暂停与较高的并发症发生率显著相关，尤其是在术后即刻和早期阶段。皮肤改变、皮瓣坏死、血清肿形成及临床感染等并发症与持续激素治疗存在显著关联（p<0.05）。其他并发症未见显著差异。 结论：初步研究结果表明，围手术期持续激素治疗可能与乳房重建术后并发症的发生存在潜在关联。

原文链接：

Optimizing Outcomes in Breast Reconstruction: The Role of Hormonal Therapy Management