Breast cancer remains the most prevalent cancer among women globally, with significant links to obesity and lipid metabolism abnormalities. This review examines the role of lipid metabolism in breast cancer progression, highlighting its multifaceted contributions to tumor biology. We discuss key metabolic processes, including fatty acid metabolism, triglyceride metabolism, phospholipid metabolism, and cholesterol metabolism, detailing the reprogramming that occurs in these pathways within breast cancer cells. Alterations in lipid metabolism are emphasized for their roles in supporting energy production, membrane biogenesis, and tumor aggressiveness. Furthermore, we examine how lipid metabolism influences immune responses in the tumor microenvironment, affecting immune cell function and therapeutic efficacy. The potential of lipid metabolism as a target for novel therapeutic strategies is also addressed, with a focus on inhibitors of key metabolic enzymes. By integrating lipid metabolism with breast cancer research, this review underscores the importance of lipid metabolism in understanding breast cancer biology and developing treatment approaches aimed at improving patient outcomes.
乳腺癌仍是全球女性中最常见的癌症，其发生与肥胖及脂质代谢异常密切相关。本文综述了脂质代谢在乳腺癌进展中的作用，重点探讨其对肿瘤生物学的多维度影响。我们系统分析了脂肪酸代谢、甘油三酯代谢、磷脂代谢及胆固醇代谢等关键代谢过程，详细阐述了乳腺癌细胞中这些代谢途径的重编程现象。研究强调脂质代谢的改变在支持能量生成、膜生物合成及肿瘤侵袭性等方面发挥重要作用。此外，本文探讨了脂质代谢如何影响肿瘤微环境中的免疫应答，包括对免疫细胞功能及治疗效果的调控作用。同时聚焦关键代谢酶抑制剂，论述了靶向脂质代谢作为新型治疗策略的潜力。通过整合脂质代谢与乳腺癌研究，本综述强调了脂质代谢在理解乳腺癌生物学机制及开发改善患者预后的治疗策略中的重要意义。
Lipid Metabolism in Breast Cancer: From Basic Research to Clinical Application
肿瘤(癌症)患者之家