Objectives: The aim of this study was to establish the concordance between conventional 20 Mhz ultrasonography and an ultrawide-field (UWF) imaging system (Optos®California) in the measurement of basal diameters of melanocytic choroidal tumors. Methods: A retrospective study comparing diagnostic tests was conducted in patients with untreated melanocytic choroidal lesions (either nevus or melanoma) who had undergone both UWF imaging and ultrasonography. Only cases with a clear visualization of tumor borders in both imaging modalities were included. Longitudinal and transversal base diameters of the melanocytic tumors were measured by 20 MHz US (one observer) and UWF fundus photography (two observers). Interobserver agreement was assessed for UWF imaging first to validate the technique. Then, UWF imaging measurements were compared with 20 MHz US results. Results: In total, 106 patient images were reviewed, of which 61 were excluded due to unclear visualization of tumor margins. We found excellent concordance (from ICC and defined Bland–Altman plots) for interobserver and inter-technique agreement in estimating basal diameters when using pseudocolor composite and red laser images by comparing them with 20 MHz US results. Conclusions: UWF fundus imaging, when complete visualization of the tumor margins is possible, could be as reliable as ultrasonography in the measurement of the basal diameters of choroidal melanocytic tumors.
目的：本研究旨在评估传统20 MHz超声与超广角成像系统在测量脉络膜黑色素性肿瘤基底直径方面的一致性。方法：本研究对未经治疗的脉络膜黑色素性病变患者进行回顾性诊断试验比较，所有患者均接受了超广角成像和超声检查。仅纳入两种成像方式下肿瘤边界均清晰可见的病例。由一名观察者通过20 MHz超声测量肿瘤的纵向和横向基底直径，由两名观察者通过超广角眼底摄影进行测量。首先评估超广角成像的观察者间一致性以验证技术可靠性，随后将超广角成像测量结果与20 MHz超声结果进行比较。结果：共分析106例患者影像，其中61例因肿瘤边界显示不清被排除。通过组内相关系数和Bland-Altman分析发现，使用伪彩色合成图像和红色激光图像时，观察者间及技术间在评估基底直径方面具有极佳的一致性。结论：当能够完整显示肿瘤边界时，超广角眼底成像在测量脉络膜黑色素性肿瘤基底直径方面与超声检查具有同等可靠性。
肿瘤(癌症)患者之家