文章：

接受癌症药物治疗门诊患者口腔不良事件及口腔管理需求的横断面调查

A Cross-Sectional Survey of Oral Adverse Events and Oral Management Needs in Outpatients Receiving Cancer Drug Therapy

原文发布日期：14 February 2025

DOI: 10.3390/cancers17040641

类型: Article

开放获取: 是

英文摘要：

Objectives:The aim of this study was to investigate the incidence and severity of oral adverse events in outpatients receiving cancer drug therapy and the need for oral management by medical professionals.Methods:A questionnaire-based survey was conducted among patients who received cancer drug therapy at our hospital between 1 and 30 September 2022. The incidence and severity of oral adverse events and the need for intervention by medical professionals were investigated. The risk factors for these events were also analyzed.Results:Of the 216 patients who answered the questionnaire, 127 (58.8%) experienced oral adverse events such as dysgeusia, oral mucositis, and xerostomia. Of the patients who experienced oral adverse events, 53.5% expressed that they wanted to improve their condition, 34.6% expressed that the adverse events affected their quality of life, and 26.8% wanted dental intervention. Thirty-two patients (25.2%) reported that the symptoms of these oral events were as severe as or more severe than those of other adverse events. The incidence of adverse oral events was significantly higher in patients treated with 5FU- and taxane-based regimens than in patients treated with other regimens.Conclusions:Our results suggest that cancer drug therapy, and the frequency and severity of oral adverse events, have a significant impact on the outpatients’ quality of life. More than a quarter of outpatients receiving cancer drug therapy wanted oral management through dental interventions. In particular, patients receiving 5FU-, taxane-, and anthracycline-based regimens may require oral management by medical professionals.

摘要翻译： 

目的：本研究旨在调查门诊癌症药物治疗患者口腔不良事件的发生率与严重程度，以及医疗专业人员实施口腔管理的必要性。 方法：于2022年9月1日至30日期间，对本院接受癌症药物治疗的门诊患者进行问卷调查。调查内容包括口腔不良事件的发生率、严重程度、对医疗干预的需求，并分析相关风险因素。 结果：在216名完成问卷的患者中，127名（58.8%）出现味觉障碍、口腔黏膜炎、口干等口腔不良事件。其中，53.5%的患者希望改善症状，34.6%认为不良事件影响生活质量，26.8%希望获得口腔专科干预。32名患者（25.2%）报告口腔症状的严重程度不低于其他药物不良反应。使用5FU类和紫杉烷类方案治疗的患者，其口腔不良事件发生率显著高于其他治疗方案。 结论：研究结果表明，癌症药物治疗及其引发的口腔不良事件的发生频率与严重程度，显著影响门诊患者的生活质量。超过四分之一接受癌症药物治疗的门诊患者希望通过口腔干预进行症状管理。特别是接受5FU类、紫杉烷类及蒽环类药物治疗的患者，可能需要医疗专业人员提供专门的口腔管理支持。

原文链接：

A Cross-Sectional Survey of Oral Adverse Events and Oral Management Needs in Outpatients Receiving Cancer Drug Therapy