文章：

放射治疗在高危非肌层浸润性膀胱癌中的前景

The Promise of Radiotherapy in High-Risk Non-Muscle Invasive Bladder Cancer

原文发布日期：13 February 2025

DOI: 10.3390/cancers17040628

类型: Article

开放获取: 是

英文摘要：

Global shortages, toxicities, and high levels of incomplete treatment with Bacillus Calmette Guerin (BCG) for non-muscle invasive bladder cancer has resulted in increasing interest in alternative treatments. Radiotherapy is not the standard of care for non-muscle invasive bladder cancer (NMIBC), despite being routinely used in muscle invasive bladder cancer. Modern techniques and advances in technology mean that radiotherapy can be delivered with increased precision in reducing normal tissue damage. Developing novel biomarker approaches, together with combination approaches with radiosensitisers and other systemic treatments, means that radiotherapy could offer greater benefits than current treatments with BCG or surgery. This review summarises the current landscape and future potential of radiotherapy for high-risk NMIBC.

摘要翻译： 

针对非肌层浸润性膀胱癌，卡介苗（BCG）的全球性短缺、毒性反应以及高比例的不完全治疗现状，促使人们日益关注替代治疗方案。尽管放疗常规用于肌层浸润性膀胱癌，但目前并非非肌层浸润性膀胱癌（NMIBC）的标准治疗手段。现代技术与治疗手段的进步使得放疗能够以更高精度实施，从而减少对正常组织的损伤。通过开发新型生物标志物检测方法，并结合放射增敏剂及其他全身治疗手段，放疗有望为高风险NMIBC患者提供优于当前BCG或手术治疗的效果。本综述旨在总结放疗在高风险NMIBC治疗领域的现状及未来潜力。

原文链接：

The Promise of Radiotherapy in High-Risk Non-Muscle Invasive Bladder Cancer