Background/Objectives: The incidence and mortality of early-onset cancers have been rising in recent decades. While epidemiological studies have examined various types of cancer, updated global data on alcohol-attributable primary liver cancer (PLC) in young adults remains limited. Methods: This study utilized data from the Global Burden of Disease (GBD) study spanning 2000 to 2021 to evaluate the age-standardized incidence, mortality, and corresponding rates of alcohol-attributable PLC among young adults aged 15–49 years. Results: In 2021, there were 8290 incidence cases and 6590 deaths from alcohol-attributable PLC in young adults. The age-standardized incidence rate has increased in Europe (annual percent change [APC]: 0.44%, 95%CI 0.35 to 0.54%), Southeast Asia (APC: 0.40%, 95% CI 0.37 to 0.44%), and the Western Pacific region (APC: 0.65%, 95% CI 0.44 to 0.86%). In 2021, alcohol-attributable PLC in young adults represented 11% (+2% from 2000) of incident cases and 11% of (+2% from 2000) deaths among all PLC in young adults. About half of the countries showed an increase in the age-standardized incidence rate of alcohol-attributable PLC among young adults between 2000 and 2021. Conclusions: The incidence rate of alcohol-attributable liver cancer in young adults has shifted significantly over the past two decades, with notable increases in Europe and the Asia–Pacific region. This trend underscores the need for global strategies to address the rising prevalence of alcohol use disorder and alcohol-associated liver disease and their impact on young adults.
背景/目的：近几十年来，早发性癌症的发病率和死亡率持续上升。尽管流行病学研究已涵盖多种癌症类型，但关于酒精相关性原发性肝癌在年轻成人群体中的最新全球数据仍较为有限。方法：本研究利用2000年至2021年全球疾病负担研究数据，评估15-49岁年轻成人酒精相关性原发性肝癌的年龄标准化发病率、死亡率及其变化趋势。结果：2021年全球年轻成人酒精相关性原发性肝癌新发病例为8290例，死亡病例为6590例。欧洲（年度变化百分比[APC]：0.44%，95%CI 0.35-0.54%）、东南亚（APC：0.40%，95%CI 0.37-0.44%）和西太平洋地区（APC：0.65%，95%CI 0.44-0.86%）的年龄标准化发病率均呈上升趋势。2021年，年轻成人酒精相关性原发性肝癌占该年龄段所有原发性肝癌新发病例的11%（较2000年增长2%），死亡病例占比同样为11%（较2000年增长2%）。2000年至2021年间，约半数国家的年轻成人酒精相关性原发性肝癌年龄标准化发病率呈现增长态势。结论：过去二十年间，年轻成人酒精相关性肝癌的发病率发生显著变化，欧洲和亚太地区的增长尤为明显。这一趋势凸显了制定全球性策略的必要性，以应对日益增长的酒精使用障碍和酒精相关性肝病及其对年轻成人健康的影响。
Young Adults and Alcohol-Associated Liver Cancer: Incidence and Death from 2000 to 2021
肿瘤(癌症)患者之家