文章：

胶质瘤背景下的表观转录组学：简要概述

Epitranscriptomics in the Glioma Context: A Brief Overview

原文发布日期：8 February 2025

DOI: 10.3390/cancers17040578

类型: Article

开放获取: 是

英文摘要：

Epitranscriptomics, the study of chemical modifications in RNA, has emerged as a crucial field in cellular regulation, adding another layer to the established landscape of DNA- and histone-based epigenetics. A wide range of RNA modifications, including N6-methyladenosine, pseudouridine, and inosine, have been identified across nearly all RNA species, influencing essential processes such as transcription, splicing, RNA stability, and translation. In the context of brain tumors, particularly gliomas, specific epitranscriptomic signatures have been reported to play a role in tumorigenesis. Despite growing evidence, the biological implications of various RNA modifications remain poorly understood. This review offers an examination of the main RNA modifications, the interplay between modified and unmodified molecules, how they could contribute to glioma-like phenotypes, and the therapeutic impact of targeting these mechanisms.

摘要翻译： 

表观转录组学，即对RNA化学修饰的研究，已成为细胞调控的关键领域，为基于DNA和组蛋白的表观遗传学增添了新的调控层面。从N6-甲基腺苷、假尿苷到肌苷等多种RNA修饰已在几乎所有RNA类型中被发现，这些修饰影响着转录、剪接、RNA稳定性及翻译等核心生物学过程。在脑肿瘤特别是胶质瘤的研究中，特定的表观转录组特征已被证实参与肿瘤发生发展。尽管相关证据不断积累，但各类RNA修饰的生物学意义仍未得到充分阐释。本综述系统探讨了主要RNA修饰类型、修饰与非修饰分子间的相互作用机制、这些修饰如何影响胶质瘤表型形成，以及靶向这些调控机制的治疗潜力。

原文链接：

Epitranscriptomics in the Glioma Context: A Brief Overview