Background/Objectives: Patients with germ cell tumors have a good prognosis, which is partly due to platin-based chemotherapy. However, the long-term effects of CTx may play a relevant role in the long-term effects. Up to now, little is known about the knowledge that testicular tumor survivors have about these long-term effects. Methods: A survey of testicular tumor patients treated at the University Hospital Dresden from 2011 up to 2021 was conducted. Patients who had received CTx were asked about their knowledge of the therapy and long-term effects. Results: Of the 279 returns (6 deceased, 46 unavailable, 64% response), 198 patients had received CTx. This was followed up by 63 different urologists. The follow-up period was 5.3 ± 2.9 years. A total of 5% (10/197) did not remember receiving CTx. A total of 55% (102/187) could not name the type of CTx. The most commonly known long-term effects were the risk of second tumors (63%) and andrological problems (59–60%). A total of 18.7% of patients did not know any long-term effects. Half of the patients (54.3%) knew a maximum of 5/14 long-term effects. In a multivariate analysis, a low educational degree (OR 2.2 (1.2–4.3);p= 0.02) and one course of carboplatin (OR 3.1 (1.1–9.3);p= 0.04) were the independent predictors for a knowledge deficit. Conclusions: Germ cell tumor patients have a low level of awareness of the long-term effects of CTx. This results in a risk of inadequate prevention and follow-up, which, in turn, may have an impact on patients’ long-term survival.
背景/目的：生殖细胞肿瘤患者预后良好，部分归功于铂类化疗。然而，化疗的长期效应可能在远期影响中发挥重要作用。迄今为止，关于睾丸肿瘤幸存者对这类长期影响的认知情况尚不明确。方法：对2011年至2021年间在德累斯顿大学医院接受治疗的睾丸肿瘤患者开展问卷调查。接受过化疗的患者被问及对治疗方案及其长期影响的认知情况。结果：在279份有效问卷（6例死亡，46例失访，回收率64%）中，198例患者曾接受化疗。后续随访由63位不同的泌尿科医生完成，平均随访时间为5.3±2.9年。5%（10/197）的患者不记得曾接受化疗，55%（102/187）无法说出具体化疗方案类型。认知度最高的长期影响为继发肿瘤风险（63%）和男科相关问题（59-60%）。18.7%的患者对任何长期影响均不知晓，半数患者（54.3%）对14项长期影响的认知不超过5项。多变量分析显示，低教育程度（OR 2.2（1.2-4.3）；p=0.02）和单疗程卡铂治疗（OR 3.1（1.1-9.3）；p=0.04）是认知缺陷的独立预测因素。结论：生殖细胞肿瘤患者对化疗长期影响的认知水平较低，这可能导致预防和随访不足的风险，进而可能影响患者的长期生存。
Knowledge Deficit About How Chemotherapy Affects Long-Term Survival in Testicular Tumor Patients
肿瘤(癌症)患者之家