Ionizing radiation is mutagenic and carcinogenic, and it is reported to induce primary and secondary tumors with intestinal tumors being one of the most commonly observed. However, the pathological and molecular mechanism(s) underlying the radiation-associated tumorigenesis remain unclear. A link between radiation and somatic tumorigenesis partly through genetic, epigenetic alteration and/or regulation of mismatch repair (MMR) genes has been hypothesized for the first time within this review. Clinical observations and experimental findings provide significant support for this association including MMR mutations as well as altered MMR RNA and protein expressions that occurred post-exposure, although existing evidence in published literature is sparse in this niche area. Some speculative mechanisms are suggested with this review to inform future research. Further studies are needed to understand the roles of the MMR system in response to radiation and to test this possible connection which could potentially provide useful and urgently needed information for clinical guidance.
电离辐射具有致突变性与致癌性，据报告可诱发原发性和继发性肿瘤，其中肠道肿瘤是最常见的类型之一。然而，辐射相关肿瘤发生的病理及分子机制尚未明确。本综述首次提出假说：辐射与体细胞肿瘤发生之间的关联，部分可能通过错配修复（MMR）基因的遗传学改变、表观遗传学改变和/或调控实现。尽管现有文献中该细分领域证据有限，但临床观察与实验结果为此关联提供了重要支持，包括辐射暴露后出现的MMR基因突变以及MMR RNA和蛋白表达的改变。本综述提出了一些推测性机制，以期为未来研究提供方向。需进一步研究以理解MMR系统对辐射的响应机制，并验证这一潜在关联，这可能为临床指导提供急需且有价值的信息。
肿瘤(癌症)患者之家