Background/Objectives: We investigated the association between chronic rhinosinusitis (CRS) and cancer risk in an adult Korean population. Methods: This retrospective cohort study used data from the Korean National Health Insurance Service database. To ensure comparability between the groups, adjustments were made for potential confounding factors, including sex, age, residence, household income, diabetes, hypertension, and chronic kidney disease. The primary endpoint was the presence of newly diagnosed cancer. Results: Among 1,337,120 individuals in the nationally representative cohort database, 10,567 patients with CRS were identified and matched with 42,268 control subjects without CRS. Patients with CRS had a significantly higher risk of overall cancer events than controls. The adjusted hazard ratio (HR) for cancer in the CRS group was 1.16 (95% confidence interval [CI]: 1.05–1.28). Notably, female patients with CRS had an elevated risk of incident cancer events. Furthermore, patients with CRS without nasal polyps exhibited a significantly increased risk of cancer, whereas those with CRS with nasal polyps did not show a similar association. Conclusions: These findings underscore the need for physicians to carefully monitor patients with CRS for potential cancer progression and develop appropriate therapeutic strategies to mitigate the impact of this condition.
背景/目的：本研究旨在探讨韩国成年人群中慢性鼻窦炎（CRS）与癌症风险之间的关联。方法：这项回顾性队列研究基于韩国国民健康保险服务数据库的数据。为确保组间可比性，对性别、年龄、居住地、家庭收入、糖尿病、高血压及慢性肾脏病等潜在混杂因素进行了调整。主要终点为新诊断癌症的发生情况。结果：在全国代表性队列数据库的1,337,120名个体中，共识别出10,567例CRS患者，并与42,268名无CRS的对照者进行匹配。结果显示，CRS患者发生总体癌症事件的风险显著高于对照组。CRS组患癌的校正风险比（HR）为1.16（95%置信区间[CI]：1.05–1.28）。值得注意的是，女性CRS患者的癌症发生风险显著升高。此外，不伴鼻息肉的CRS患者表现出显著的癌症风险增加，而伴有鼻息肉的CRS患者则未观察到类似关联。结论：这些发现提示临床医生需对CRS患者进行密切监测，警惕其潜在的癌症进展风险，并制定适当的治疗策略以减轻该疾病的影响。
肿瘤(癌症)患者之家