Background:Global colorectal cancer (CRC) incidence is significant, constituting 15% of all cancer cases with 1.4 million new diagnoses annually. Recent research suggests categorizing CRC into three clinical groups: right colon cancer (RCC), left colon cancer (LCC), and rectal cancer, each with distinct embryological and molecular characteristics.Methods: A retrospective analysis of 189 patients (103 men, 86 women) undergoing surgery for RCC and LCC from January 2018 to December 2023 was performed.Results: LCC was a more common localization (98, 51.85%) than RCC (91, 48.15%). Patients with RCC were older than patients with LCC (70 (36–92, IQR 11) vs. 68 (38–84, IQR 12.5) years;p= 0.02). The duration of surgical procedure was comparable in both groups (225 (120–420, IQR 80) vs. 210 (105–505, IQR 85) minutes;p= 0.16). Complications occurred in 16 (17.58%) patients with RCC and in 15 (15.31%) patients with LCC (p= 0.72). One-year overall survival was 92.76% (SE 2.16%) (91.57% (SE 3.43%) in the RCC group and 93.99% (SE 2.61%) in the LCC group;p= 0.79).Conclusions:Colon cancer incidence is increasing globally due to economic and lifestyle factors. Our study reflects this trend, noting a rise in cases from 2018 to 2023. Despite several differences, overall survival rates do not significantly differ between RCC and LCC patients. Understanding clinical disparities is crucial for optimizing patient outcomes.
背景：全球结直肠癌（CRC）发病率显著，占所有癌症病例的15%，每年新增诊断140万例。近期研究建议将CRC分为三个临床亚型：右半结肠癌（RCC）、左半结肠癌（LCC）和直肠癌，每种亚型具有不同的胚胎学及分子特征。 方法：本研究回顾性分析了2018年1月至2023年12月期间接受手术治疗的189例RCC与LCC患者（男性103例，女性86例）。 结果：LCC（98例，51.85%）较RCC（91例，48.15%）更为常见。RCC患者年龄高于LCC患者（70岁（范围36-92，四分位距11）vs. 68岁（范围38-84，四分位距12.5）；p=0.02）。两组手术时长无显著差异（225分钟（范围120-420，四分位距80）vs. 210分钟（范围105-505，四分位距85）；p=0.16）。RCC组并发症发生率为17.58%（16例），LCC组为15.31%（15例）（p=0.72）。一年总生存率为92.76%（标准误2.16%），其中RCC组为91.57%（标准误3.43%），LCC组为93.99%（标准误2.61%）（p=0.79）。 结论：受经济与生活方式因素影响，全球结肠癌发病率持续上升。本研究反映了这一趋势，观察到2018至2023年间病例数增长。尽管存在若干差异，RCC与LCC患者的总生存率无显著统计学差异。深入理解临床差异对优化患者预后至关重要。
Right-Sided Versus Left-Sided Colon Cancer—A 5-Year Single-Center Observational Study
肿瘤(癌症)患者之家