Background: Tobacco use remains a global challenge to public health, accounting for almost eight million deaths per year worldwide, with a significant portion attributable to tobacco-related cancers. Examining the epidemiology of tobacco-related cancers and assessing the trends in the incidence and mortality will allow for more effective prevention, treatment, and targeted strategies. Methods: We assessed the trends in the incidence and mortality of tobacco-related cancers among adults in the United States using data from United States Cancer Statistics (USCS) 2001–2021 and mortality data 1975–2022 from the National Center for Health Statistics (NCHS). The incidence and mortality rates of tobacco-related cancers were calculated as cases per 1,000,000 persons and age-adjusted to the 2000 United States standard population. Results: There was a recent overall decreasing trend in both the incidence (2001–2021) and mortality rate (2001–2022). Among adults 20–49 years old, there was an increasing trend from 2001 to 2021 in the incidence among non-Hispanic American Indians/Alaska Natives (APC 2.6, 95% CI 2.1–3.0) and those in the West (APC 0.2, 95% CI 0.0–0.4); in Hispanics, the incidence rate increased most recently from 2013 to 2021 (APC 1.7, 95% CI 1.0–3.0). The mortality rate first increased from 1975 to 1990 among females 50–64 years old and males 65+ years old and from 1975 to 2000 among females 65+ years old, and then decreased thereafter. Conclusions: The rising incidence in some younger groups highlights the need for targeted public health interventions to address disparities and improve cancer prevention in these vulnerable populations.
背景：烟草使用仍是全球公共卫生面临的挑战，每年导致全球近八百万人死亡，其中相当一部分归因于烟草相关癌症。研究烟草相关癌症的流行病学特征并评估其发病率和死亡率趋势，有助于制定更有效的预防、治疗和针对性策略。 方法：我们利用美国癌症统计数据库（USCS）2001–2021年的发病数据以及美国国家卫生统计中心（NCHS）1975–2022年的死亡数据，评估了美国成年人烟草相关癌症的发病率和死亡率趋势。烟草相关癌症的发病率和死亡率按每百万人中的病例数计算，并依据2000年美国标准人口进行年龄调整。 结果：近期数据显示，烟草相关癌症的发病率（2001–2021年）和死亡率（2001–2022年）总体呈下降趋势。在20–49岁的成年人中，非西班牙裔美国印第安人/阿拉斯加原住民的发病率从2001年至2021年呈上升趋势（年度百分比变化APC 2.6，95% CI 2.1–3.0），西部地区人群的发病率也有所上升（APC 0.2，95% CI 0.0–0.4）；西班牙裔人群的发病率在最近阶段（2013–2021年）上升最为明显（APC 1.7，95% CI 1.0–3.0）。在死亡率方面，50–64岁女性及65岁以上男性的死亡率在1975–1990年间首次上升，65岁以上女性的死亡率在1975–2000年间首次上升，随后均转为下降。 结论：部分年轻群体中发病率的上升凸显了实施针对性公共卫生干预的必要性，以应对健康差异并加强这些脆弱人群的癌症预防工作。
Trends in the Incidence and Mortality of Tobacco-Related Cancers Among Adults in the United States
肿瘤(癌症)患者之家