Background/Objectives:Ovarian cancer is a leading cause of gynecological cancer mortality worldwide, often diagnosed at advanced stages due to vague symptoms and the lack of effective early detection methods. Long non-coding RNAs (lncRNAs) have emerged as key regulators in cancer biology, influencing cellular processes such as proliferation, apoptosis, and chemoresistance. This review explores the multifaceted roles of lncRNAs in ovarian cancer pathogenesis and their potential as biomarkers and therapeutic targets.Methods:A comprehensive literature review was conducted to analyze the structural and functional characteristics of lncRNAs and their contributions to ovarian cancer biology. This includes their regulatory mechanisms, interactions with signaling pathways, and implications for therapeutic resistance. Advanced bioinformatics and omics approaches were also evaluated for their potential in lncRNA research.Results:The review highlights the dual role of lncRNAs as oncogenes and tumor suppressors, modulating processes such as cell proliferation, invasion, and angiogenesis. Specific lncRNAs, such as HOTAIR and GAS5, demonstrate significant potential as diagnostic biomarkers and therapeutic targets. Emerging technologies, such as single-cell sequencing, provide valuable insights into the tumor microenvironment and the heterogeneity of lncRNA expression.Conclusions:LncRNAs hold transformative potential in advancing ovarian cancer diagnosis, prognosis, and treatment. Targeting lncRNAs or their associated pathways offers promising strategies to overcome therapy resistance and enhance personalized medicine. Continued research integrating omics and bioinformatics will be essential to unlock the full clinical potential of lncRNAs in ovarian cancer management.
背景/目的：卵巢癌是全球妇科癌症死亡的主要原因，常因症状隐匿且缺乏有效的早期检测方法而在晚期才被确诊。长链非编码RNA（lncRNA）已成为癌症生物学中的关键调控因子，影响细胞增殖、凋亡和化疗耐药等过程。本综述探讨了lncRNA在卵巢癌发病机制中的多面作用及其作为生物标志物和治疗靶点的潜力。 方法：通过全面的文献综述，分析lncRNA的结构与功能特征及其在卵巢癌生物学中的作用，包括其调控机制、与信号通路的相互作用以及对治疗耐药的影响。同时评估了先进生物信息学和组学方法在lncRNA研究中的应用潜力。 结果：综述强调了lncRNA作为癌基因和抑癌基因的双重角色，调控细胞增殖、侵袭和血管生成等过程。特定lncRNA（如HOTAIR和GAS5）显示出作为诊断生物标志物和治疗靶点的显著潜力。单细胞测序等新兴技术为肿瘤微环境及lncRNA表达的异质性提供了重要见解。 结论：lncRNA在推动卵巢癌诊断、预后和治疗方面具有变革性潜力。靶向lncRNA或其相关通路为克服治疗耐药和促进个体化医疗提供了有前景的策略。未来结合组学与生物信息学的持续研究，对于充分挖掘lncRNA在卵巢癌管理中的临床潜力至关重要。
Long Non-Coding RNAs in Ovarian Cancer: Mechanistic Insights and Clinical Applications
肿瘤(癌症)患者之家