Background. In recent years, the role of prostate-specific membrane antigen (PSMA) in the imaging and treatment of prostate cancer (PCa) has been extensively investigated. However, despite its name, PSMA is not exclusively specific to PCa. It has been found to be expressed in the neo-vasculature of various solid tumors, including breast cancer (BC), in which it is associated with tumor angiogenesis. Methods. This review aims to assess the potential of PSMA-based radiopharmaceuticals for BC diagnosis and treatment. It explores the current landscape by analyzing preclinical and clinical studies, as well as ongoing clinical trials, to provide insights into the PSMA-targeted approaches in BC management. Results. Early studies suggest PSMA-based imaging could improve BC lesion detection, especially in TNBC. The available data remains too preliminary to conclusively assess whether PSMA-based imaging or therapy will offer a significant advantage in BC. However, some preclinical findings suggest that this approach may hold promise as a novel strategy for managing this widespread malignancy. Conclusions. PSMA-based strategies show potential for BC diagnosis and treatment, but further research is needed. Ongoing and future clinical trials are expected to provide deeper insights into the potential utility of this approach.
背景。近年来，前列腺特异性膜抗原（PSMA）在前列腺癌（PCa）的影像学诊断与治疗中的作用已得到广泛研究。然而，尽管其名称如此，PSMA并非仅对PCa特异。研究发现，PSMA在包括乳腺癌（BC）在内的多种实体瘤的新生血管系统中均有表达，并与肿瘤血管生成相关。方法。本综述旨在评估基于PSMA的放射性药物在BC诊断与治疗中的潜力。通过分析临床前研究、临床研究以及正在进行的临床试验，探讨当前研究现状，以期为BC治疗中PSMA靶向策略提供见解。结果。早期研究表明，基于PSMA的影像学检查可能改善BC病灶的检测，特别是在三阴性乳腺癌（TNBC）中。现有数据仍处于初步阶段，尚无法最终评估基于PSMA的影像学或治疗方法是否能为BC带来显著优势。然而，一些临床前研究结果表明，这一策略可能为治疗这种广泛存在的恶性肿瘤提供新的希望。结论。基于PSMA的策略在BC诊断与治疗中显示出潜力，但需要进一步研究。正在进行和未来的临床试验有望为这一方法的潜在应用提供更深入的见解。
Unveiling Prostate-Specific Membrane Antigen’s Potential in Breast Cancer Management
肿瘤(癌症)患者之家