Background/Objectives: Cancer prevalence is increasing globally due to aging populations. Certain lifestyles are associated with cancer; however, the long-term combined effects of lifestyle factors on cancer has not been investigated. This study aimed to investigate the cumulative effect of lifestyle risk factors over 8 years on cancer in older Korean men. Methods: We assessed 64,756 men aged ≥65 years at the baseline year (2008–2009) using data from the National Health Insurance Service-Senior Cohort. Lifestyle factors, including smoking status, alcohol consumption, and physical activity, were evaluated over four consecutive phases (2002–2003, 2004–2005, 2006–2007, and 2008–2009) of health check-ups, and each participant’s overall lifestyle risk score was calculated after considering the value of a single poor lifestyle factor in each phase as 1, with a cumulative score ranging between 0 and 12. According to the lifestyle risk scores, the hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazard regression analysis. Results: Of the 64,756 men, 13,130 cases of cancer developed. The risk of cancer increased as the number of poor lifestyle factors and lifestyle risk score increased from the baseline year during the four phases. Compared to a score of 0–2, the HRs for cancer were 1.10 (0.98–1.23), 1.54 (1.37–1.73), and 1.72 (1.48–1.99) for scores of 3–5, 6–8, and 9–12, respectively. Conclusions: The risk of cancer increased as the cumulative burden of poor lifestyle habits over 8 years increased. Therefore, practicing and maintaining healthy lifestyles is crucial to preventing cancer in older Korean men.
**背景/目的：** 随着人口老龄化，全球癌症患病率持续上升。某些生活方式与癌症相关；然而，生活方式因素对癌症的长期综合影响尚未得到充分研究。本研究旨在探讨韩国老年男性中，长达8年的生活方式风险因素的累积效应对癌症发生的影响。 **方法：** 本研究利用韩国国民健康保险服务-老年队列的数据，评估了基线年份（2008-2009年）64,756名年龄≥65岁的男性。在连续四个阶段的健康检查（2002-2003年、2004-2005年、2006-2007年和2008-2009年）中，评估了包括吸烟状况、饮酒量和体力活动在内的生活方式因素。将每个阶段中单个不良生活方式因素赋值为1，计算每位参与者的总体生活方式风险评分，累积评分范围为0至12分。根据生活方式风险评分，使用Cox比例风险回归分析计算了风险比及其95%置信区间。 **结果：** 在64,756名男性中，共发生13,130例癌症。随着四个阶段中不良生活方式因素数量的增加以及从基线年开始累积的生活方式风险评分的升高，癌症风险也随之增加。与评分为0-2分者相比，评分为3-5分、6-8分和9-12分者的癌症风险比分别为1.10、1.54和1.72。 **结论：** 随着8年间不良生活习惯累积负担的增加，癌症风险也随之升高。因此，践行并维持健康的生活方式对于预防韩国老年男性的癌症至关重要。
肿瘤(癌症)患者之家