Objective: Resection of colloid cysts, a rare third ventricle pathology, is accepted clinical practice. Owing to their location proximal to deep gray nuclei and forniceal columns, colloid cysts have been theorized to contribute to cognitive decline. Comprehensive pre- and post-operative cognitive testing, however, has rarely been implemented. Methods: We analyzed formal neuropsychological testing performed in 20 patients undergoing endoscopic cyst resection. Pre- and post-operative performance was compared either for each individual patient or according to aggregated neuropsychological factor scores grouped via expert census. A change in performance was deemed significant if (i) it reached statistical significance and (ii) was greater than 1.5 pre-operative standard deviations. Results: Twenty patients with colloid cysts (average diameter 13.3 ± 1.3 mm) underwent matched pre- and post-operative testing. No patient had a significant change in cognitive performance. Neurocognitive metrics assessing cognitive functions typically subsumed by the temporal (p= 0.35), extratemporal (p= 0.20), occipitoparietal (p= 0.31), or frontal lobes (p= 0.11) did not change post-operatively. Similarly, no differences emerged when factor scores were generated according to composite scores of different neurocognitive domains: attention (p= 0.32), executive function (p= 0.14), language (p= 0.98), and visuospatial function (p= 0.42). Conclusions: Neuropsychological testing allows for the careful monitoring of cognitive status before and after surgery and for the identification of patients who may benefit from pre- and post-operative cognitive rehabilitation. It should also be used as a valuable surgical psychometric marker and adjuvant. No significant cognitive decline was observed in this cohort.
目的：胶样囊肿是一种罕见的第三脑室病变，手术切除是公认的临床实践。由于其位置邻近深部灰质核团和穹窿柱，理论上认为胶样囊肿可能导致认知功能下降。然而，全面的术前和术后认知测试却很少实施。方法：我们分析了20例接受内镜下囊肿切除术患者进行的正式神经心理学测试。通过比较每位患者术前与术后的表现，或根据专家共识分组汇总的神经心理学因子得分进行评估。若满足以下两个条件，则认为表现变化具有显著性：(i) 达到统计学显著性；(ii) 变化幅度大于术前标准差的1.5倍。结果：20例胶样囊肿患者（平均直径13.3 ± 1.3毫米）完成了匹配的术前与术后测试。所有患者均未出现显著的认知功能变化。评估通常由颞叶（p=0.35）、颞外区（p=0.20）、枕顶叶（p=0.31）或额叶（p=0.11）主导的认知功能的神经认知指标在术后均未发生改变。同样，根据不同神经认知领域的综合评分生成的因子得分也未显示差异：注意力（p=0.32）、执行功能（p=0.14）、语言功能（p=0.98）和视觉空间功能（p=0.42）。结论：神经心理学测试可用于手术前后认知状态的精细监测，并有助于识别可能受益于术前和术后认知康复的患者。它还应作为一种有价值的手术心理测量指标和辅助工具。本队列研究中未观察到显著的认知功能下降。
肿瘤(癌症)患者之家