Background/Objectives: Ovarian cancer is the fifth most common cancer among women, with an estimated 19,680 new cases projected in 2024. Adjuvant chemotherapy remains the standard treatment for epithelial ovarian cancers but is frequently associated with adverse events, such as chemotherapy-induced alopecia (CIA). CIA is a particularly distressing side effect that significantly affects the body image, self-esteem, and quality of life of patients. Unfortunately, CIA remains underexplored in patients with ovarian cancer. Methods: This scoping review analyzed PubMed- and EMBASE-indexed studies investigating the incidence, severity, and mechanisms of CIA in ovarian cancer patients. Eighteen studies were included for analysis. Results: Our analysis identified platinum-based compounds, taxanes, and topoisomerase I inhibitors as the agents most strongly correlated with severe alopecia, particularly in combination regimens such as carboplatin–paclitaxel (CP), and cyclophosphamide, adriamycin, and cisplatin (CAP). Among the monotherapies, taxanes, including paclitaxel and docetaxel, posed the highest risk of CIA. Mild-to-moderate alopecia was observed in patients treated with gemcitabine or pegylated liposomal doxorubicin. Alternative factors such as dosing schedules and prior chemotherapy exposure also significantly influence CIA severity. Conclusions: Given the profound psychosocial impact of CIA, optimizing treatment protocols to reduce the severity of alopecia without compromising therapeutic efficacy is crucial. These findings offer insights that may guide future therapeutic strategies for improving patient outcomes and quality of life.
背景/目的：卵巢癌是女性第五大常见恶性肿瘤，2024年预计新增病例约19,680例。辅助化疗仍是上皮性卵巢癌的标准治疗方案，但常伴随化疗相关脱发等不良事件。化疗所致脱发作为严重影响患者体像、自尊及生活质量的副作用，其临床研究在卵巢癌领域尚显不足。方法：本范围综述通过检索PubMed与EMBASE数据库，系统分析卵巢癌患者化疗相关脱发的发生率、严重程度及作用机制，最终纳入18项研究进行综合分析。结果：分析显示铂类化合物、紫杉烷类及拓扑异构酶I抑制剂与重度脱发显著相关，尤以卡铂-紫杉醇联合方案及环磷酰胺-阿霉素-顺铂方案为甚。单药治疗中，紫杉醇与多西他赛等紫杉烷类药物导致脱发的风险最高。吉西他滨或聚乙二醇化脂质体阿霉素治疗患者则多表现为轻中度脱发。给药方案及既往化疗史等变量亦对脱发严重程度产生显著影响。结论：鉴于化疗相关脱发对患者心理社会功能的深远影响，在保障疗效的前提下优化治疗方案以减轻脱发程度至关重要。本研究为未来制定提升患者生存质量的治疗策略提供了重要参考依据。
肿瘤(癌症)患者之家