文章：

术前膈肌萎缩增加肺癌切除术后肺部并发症风险：一项初步研究

Preoperative Diaphragm Muscle Atrophy Increases the Likelihood of Postoperative Pulmonary Complications After Lung Cancer Resection: A Pilot Study

原文发布日期：23 January 2025

DOI: 10.3390/cancers17030373

类型: Article

开放获取: 是

英文摘要：

Background/Objectives: Various conditions contribute to the development of postoperative pulmonary complications (PPCs) following thoracic surgery. In this study, the aim was to investigate whether preoperative diaphragm dysfunction is associated with an increased risk of PPCs after lung cancer resection.Methods: We prospectively examined 45 patients scheduled for video-assisted thoracoscopic surgery (VATS) lobectomy or open thoracotomy. Relevant clinical data were retrieved from hospital database records, while diaphragm muscles were assessed using ultrasound.Results: Our results demonstrated that preoperative diaphragm muscle atrophy was significantly associated with a higher risk of developing PPCs compared to patients with normal diaphragm thickness. Diaphragm atrophy was also linked to prolonged hospital stays. Additionally, we observed a moderate correlation between expiratory diaphragm thickness and the number of PPCs.Conclusions: Low diaphragm expiratory thickness is associated with postoperative pulmonary complications after lobectomy for lung cancer. Importantly, unlike other predictive factors such as age, COPD, or smoking, diaphragmatic atrophy is a modifiable risk factor that can potentially be addressed through early therapeutic intervention.

摘要翻译： 

背景/目的：多种因素可导致胸外科术后肺部并发症的发生。本研究旨在探讨术前膈肌功能障碍是否会增加肺癌切除术后发生肺部并发症的风险。方法：我们前瞻性纳入了45例计划接受电视辅助胸腔镜肺叶切除术或开胸手术的患者。相关临床数据从医院数据库记录中提取，同时使用超声评估膈肌状况。结果：研究结果显示，与膈肌厚度正常的患者相比，术前膈肌萎缩与发生术后肺部并发症的风险显著升高相关。膈肌萎缩还与住院时间延长有关。此外，我们观察到呼气相膈肌厚度与术后肺部并发症数量之间存在中度相关性。结论：呼气相膈肌厚度偏低与肺癌肺叶切除术后肺部并发症的发生相关。重要的是，与年龄、慢性阻塞性肺疾病或吸烟等其他预测因素不同，膈肌萎缩是一种可干预的风险因素，有可能通过早期治疗干预加以改善。

原文链接：

Preoperative Diaphragm Muscle Atrophy Increases the Likelihood of Postoperative Pulmonary Complications After Lung Cancer Resection: A Pilot Study