Periprostatic adipose tissue (PPAT) contributes to the pathogenesis of prostate cancer. The purpose of this study was to review and summarize the literature on the role of PPAT in prostate cancer pathogenesis. Moreover, we evaluated the clinical implication of PPAT in patients with prostate cancer. We performed a scoping literature review of PubMed from January 2002 to November 2024. Search terms included “periprostatic adipose tissue”, “adipokines”, and “prostate cancer”. Secondary search involved reference lists of eligible articles. The key criterion was to identify studies that included PPAT, adipokines, and their role in prostate cancer biology and clinical features. In total 225 publications were selected for inclusion in this review. The studies contained in publications allowed us to summarize the data on the pathogenesis of PPAT as a contributor to prostate cancer biology and its aggressiveness. The review also presents new research directions for PPAT as a new target for the treatment of prostate cancer. Based on the current review, it can be stated that PPAT plays an important role in prostate cancer pathogenesis. Moreover, PPAT seems to be a promising target point when it comes to finding new therapies in patients with more aggressive and/or advanced stages of prostate cancer.
前列腺周围脂肪组织（PPAT）在前列腺癌的发病机制中起着重要作用。本研究旨在系统回顾并总结关于PPAT在前列腺癌发病机制中作用的文献，同时评估PPAT在前列腺癌患者中的临床意义。我们于2002年1月至2024年11月期间对PubMed数据库进行了范围性文献综述，检索关键词包括“前列腺周围脂肪组织”“脂肪因子”及“前列腺癌”，并对符合条件文章的参考文献进行了二次检索。核心筛选标准为纳入涉及PPAT、脂肪因子及其在前列腺癌生物学行为和临床特征中作用的研究。最终共225篇文献被纳入本综述。通过对这些文献的分析，我们系统总结了PPAT作为前列腺癌生物学行为及其侵袭性影响因素的相关发病机制数据。本综述同时提出了将PPAT作为前列腺癌治疗新靶点的研究方向。基于现有研究证据可以明确，PPAT在前列腺癌发病机制中具有重要作用。此外，针对侵袭性较强和/或晚期前列腺癌患者探索新疗法时，PPAT有望成为极具前景的治疗靶点。
Periprostatic Adipose Tissue as a Contributor to Prostate Cancer Pathogenesis: A Narrative Review
肿瘤(癌症)患者之家