文章：

三聚体蛋白家族成员与处理小体：在脂肪肝病、病毒性肝炎及肝细胞癌中的复杂调控网络

Tristetraprolin Family Members and Processing Bodies: A Complex Regulatory Network Involved in Fatty Liver Disease, Viral Hepatitis and Hepatocellular Carcinoma

原文发布日期：21 January 2025

DOI: 10.3390/cancers17030348

类型: Article

开放获取: 是

英文摘要：

Chronic liver diseases, such as those encountered with obesity, chronic/abusive alcohol consumption or viral infections, represent not only major public health concerns with limited therapeutic options but also important risk factors for the onset of hepatocellular carcinoma (HCC). Deciphering the molecular traits underlying these disorders is of high interest for designing new and effective treatments. The tristetraprolin (TTP) family members are of particular importance given their ability to control the expression of a wide range of genes involved in metabolism, inflammation and carcinogenesis at the post-transcriptional level. This regulation can occur within small cytoplasmic granules, namely, processing bodies (P-bodies), where the mRNA degradation occurs. Increasing evidence indicates that TTP family members and P-bodies are involved in the development of chronic liver diseases and cancers. In this review, we discuss the role of this regulatory mechanism in metabolic-dysfunction-associated steatotic liver disease (MASLD), alcohol-related liver disease (ALD), hepatic viral infections and HCC.

摘要翻译： 

慢性肝病，如肥胖、长期/过度饮酒或病毒感染所引发的疾病，不仅是当前公共卫生领域面临的主要挑战且治疗手段有限，同时也是肝细胞癌（HCC）发生的重要风险因素。解析这些疾病背后的分子特征对于设计新型有效疗法具有重要意义。三结构域蛋白（TTP）家族成员因其能在转录后水平调控众多参与代谢、炎症和致癌过程的基因表达而显得尤为重要。这种调控可发生于细胞质内的小颗粒结构——即处理小体（P-bodies）中，mRNA降解正是在此发生。越来越多的证据表明，TTP家族成员及P-bodies参与慢性肝病和癌症的发展进程。本文综述中，我们将探讨该调控机制在代谢功能障碍相关脂肪性肝病（MASLD）、酒精相关性肝病（ALD）、肝脏病毒感染及肝细胞癌中的作用。

原文链接：

Tristetraprolin Family Members and Processing Bodies: A Complex Regulatory Network Involved in Fatty Liver Disease, Viral Hepatitis and Hepatocellular Carcinoma