文章：

肿瘤内血管血小板聚集与上皮性卵巢癌中缺氧诱导因子1α表达的相关性：对预后与分期的意义

Correlation Between Intravascular Platelet Aggregation in Tumors and Hypoxia-Inducible Factor 1 Alpha Expression in Epithelial Ovarian Cancer: Implications for Prognosis and Staging

原文发布日期：21 January 2025

DOI: 10.3390/cancers17030345

类型: Article

开放获取: 是

英文摘要：

Background/Objectives: This study aimed to evaluate the association between intravascular platelet aggregation in tumors and ovarian carcinoma prognosis and investigate underlying mechanisms. Methods: A retrospective analysis was conducted on 144 patients with ovarian carcinoma. Immunohistochemical staining for CD42b, hypoxia-inducible factor-1α (HIF-1α), platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF) was performed using tissue microarrays to assess intravascular platelet aggregation. Staining grades ranged from 1 to 3 for CD42b (platelet aggregation or microthrombus) and 0 to 3 for HIF-1α, PDGF, and VEGF. Results: Among the patients, 25 (17.4%) had grade 1 (no platelet aggregation), 85 (59.0%) had grade 2 (platelet aggregation), and 34 (23.6%) had grade 3 (microthrombus). The grade of intravascular platelet aggregation in ovarian carcinoma was statistically significantly associated with a poor prognosis (p= 0.037). In addition, in patients with more advanced stages of ovarian cancer, higher levels of intravascular platelet aggregation were observed. Additional analysis revealed a correlation between platelet aggregation and HIF-1α expression (correlation coefficient = 0.226,p= 0.006), while PDGF and VEGF showed no significant correlations. Conclusions: Intravascular platelet aggregation in tumors is associated with advanced stages and poor prognosis in ovarian carcinoma. The results of our study suggest a potential association with hypoxia induced by intravascular platelet aggregation in ovarian carcinoma.

摘要翻译： 

背景/目的：本研究旨在评估卵巢癌肿瘤内血管内血小板聚集与预后的关联，并探讨其潜在机制。方法：对144例卵巢癌患者进行回顾性分析。采用组织芯片技术对CD42b、缺氧诱导因子-1α（HIF-1α）、血小板衍生生长因子（PDGF）和血管内皮生长因子（VEGF）进行免疫组化染色，以评估血管内血小板聚集情况。CD42b（血小板聚集或微血栓）染色分级为1-3级，HIF-1α、PDGF和VEGF染色分级为0-3级。结果：患者中，25例（17.4%）为1级（无血小板聚集），85例（59.0%）为2级（血小板聚集），34例（23.6%）为3级（微血栓形成）。卵巢癌血管内血小板聚集分级与不良预后存在统计学显著关联（p=0.037）。此外，在卵巢癌分期更晚的患者中，观察到更高水平的血管内血小板聚集。进一步分析显示，血小板聚集与HIF-1α表达呈正相关（相关系数=0.226，p=0.006），而PDGF和VEGF未显示显著相关性。结论：肿瘤内血管内血小板聚集与卵巢癌晚期分期及不良预后相关。本研究结果提示，卵巢癌中血管内血小板聚集可能通过诱导缺氧机制影响疾病进展。

原文链接：

Correlation Between Intravascular Platelet Aggregation in Tumors and Hypoxia-Inducible Factor 1 Alpha Expression in Epithelial Ovarian Cancer: Implications for Prognosis and Staging