文章：

在考虑预后因素的情况下，嗅神经母细胞瘤内镜与开放手术四十年长期疗效分析

Forty-Year Long-Term Outcome After Endoscopic and Open Surgery for Esthesioneuroblastoma in Consideration of Prognostic Factors

原文发布日期：21 January 2025

DOI: 10.3390/cancers17030343

类型: Article

开放获取: 是

英文摘要：

Background:The objective of this study was to compare results after endoscopic (ES) and open surgery (OpS) for esthesioneuroblastoma over a 40-year period.Methods:In a retrospective study, patients who had undergone ES and OpS for esthesioneuroblastoma with curative intent were included. The following outcome parameters were compared after ES and OpS: epidemiologic, clinical (including known tumor classifications), histopathologic, therapeutic (resection state, adjuvant therapy), and development of recurrences. Crude survival and Kaplan–Meier 10 y, 20 y, and 35 y actuarial survival were calculated.Results:Between 1981 and 2021, 15 patients were operated with ES and 28 with OpS. Advanced-stage tumors were significantly more often treated using OpS. For all other parameters, there were no other significant differences between ES and OpS. After ES, the 35 y OS, DSS, and DFS were 48.1%, 100%, and 55.9%, respectively. After OpS, they were 40.5%, 77.5%, and 35.3%.Conclusions:ES is an effective approach in esthesioneuroblastoma, even in the long-term course over decades, if the appropriate indication compared to OpS is respected.

摘要翻译： 

背景：本研究旨在比较40年间内镜手术（ES）与开放手术（OpS）治疗嗅神经母细胞瘤的疗效差异。方法：通过回顾性研究，纳入以根治为目的接受ES或OpS治疗的嗅神经母细胞瘤患者。对比分析两组患者在流行病学特征、临床指标（包括已知肿瘤分型）、组织病理学结果、治疗方案（切除状态、辅助治疗）及复发情况等方面的差异。计算总体生存率，并采用Kaplan-Meier法评估10年、20年及35年精算生存率。结果：1981年至2021年间，共15例患者接受ES治疗，28例接受OpS治疗。晚期肿瘤患者显著更常采用OpS治疗。其余各项参数在两组间均无显著差异。ES组35年总生存率（OS）、疾病特异性生存率（DSS）和无病生存率（DFS）分别为48.1%、100%和55.9%；OpS组对应数据分别为40.5%、77.5%和35.3%。结论：若严格掌握与OpS相比的适应证，ES是治疗嗅神经母细胞瘤的有效方法，其长期疗效可维持数十年。

原文链接：

Forty-Year Long-Term Outcome After Endoscopic and Open Surgery for Esthesioneuroblastoma in Consideration of Prognostic Factors