Background/Objectives: This study describes the sequelae, side effects, and toxicities experienced by Canadian breast cancer survivors at a breast cancer survivorship clinic at a tertiary academic cancer centre and identifies potential risk factors which may be associated with increased side effect burden. Methods: A retrospective chart review was performed of adult patients treated at the Sunnybrook Breast Cancer Survivorship Clinic from 6 July 2022, to 30 September 2023 (n= 435). Results: Most patients (72.6%) reported at least one side effect impacting their quality of life, and a smaller majority (55.4%) reported two or more side effects. The most common symptoms experienced were anxiety (29.4%), chronic pain (23.9%), hot flashes (21.4%), and fear of recurrence (19.8%). Older age was strongly correlated with a lower likelihood of experiencing greater side effect burden (p< 0.01). Patients who underwent chemotherapy were significantly more likely to experience higher side effect burden than patients who did not. Current smokers were more likely than nonsmokers or past smokers to have a higher burden, for both physical (p< 0.01) and psychological side effects (p< 0.01). The multivariate analysis demonstrated that younger age was strongly associated with greater side effect burden, higher likelihood of psychological and physical symptoms, and greater likelihood of requiring close follow-up. Conclusions: The results highlight the need for survivorship resources tailored to survivors under the age of 55 and the importance of referring smokers to smoking cessation programs. Additional research is required to explore the significant reluctance among patients regarding discharge. Future studies should examine the acute needs of younger breast cancer survivors and investigate the impact of smoking and treatment modalities on the side effect burden.
背景/目的：本研究旨在描述加拿大乳腺癌幸存者在三级学术癌症中心乳腺癌生存门诊中经历的后遗症、副作用及毒性反应，并识别可能与更高副作用负担相关的潜在风险因素。方法：对2022年7月6日至2023年9月30日期间在Sunnybrook乳腺癌生存门诊接受治疗的成年患者（n=435）进行回顾性病历分析。结果：大多数患者（72.6%）报告至少有一种影响生活质量的副作用，略超半数患者（55.4%）报告存在两种及以上副作用。最常见的症状包括焦虑（29.4%）、慢性疼痛（23.9%）、潮热（21.4%）及复发恐惧（19.8%）。年龄增长与较低的副作用负担显著相关（p<0.01）。接受化疗的患者比未化疗者出现更高副作用负担的风险显著增加。当前吸烟者比非吸烟者或既往吸烟者在生理（p<0.01）和心理副作用（p<0.01）方面均承受更高负担。多变量分析显示，年轻年龄与更高的副作用负担、更易出现心理和生理症状以及需要密切随访的可能性显著相关。结论：研究结果凸显了为55岁以下幸存者定制生存支持资源的必要性，以及将吸烟者转介至戒烟计划的重要性。需进一步探究患者对出院安排的显著抵触心理。未来研究应关注年轻乳腺癌幸存者的急性需求，并深入探讨吸烟及治疗方案对副作用负担的影响机制。
肿瘤(癌症)患者之家