Background/Objectives:Pregnancy-associated cancer (PAC) presents significant challenges for maternal and neonatal health, and yet its impact on neonatal outcomes remains poorly understood. This systematic review aims to evaluate the neonatal risks associated with PAC.Methods:A systematic search of PubMed, Embase, Scopus, and other databases was conducted up to 1 November 2024, identifying observational studies and randomized controlled trials assessing neonatal outcomes in pregnancies affected by PAC. Outcomes included preterm birth, low birthweight, macrosomia, small and large for gestational age, low Apgar score, congenital anomalies, and neonatal mortality.Results:Eleven high-quality studies encompassing over 46 million births, including 9953 PAC-affected pregnancies, were reviewed. PAC significantly increased the risks of preterm birth (adjusted ORs ranging from 1.48 to 6.34) and low birthweight (adjusted ORs up to 5.5). Other adverse outcomes included low Apgar scores and neonatal mortality, primarily linked to prematurity. Cancer type and treatment timing influenced these outcomes, with gynecological and breast cancers posing higher risks.Conclusions:Neonates of mothers with PAC face increased risks of adverse outcomes, underscoring the importance of tailored, multidisciplinary management. Further prospective studies are needed to clarify the impacts of specific cancer treatments during pregnancy.
背景/目的：妊娠相关癌症（PAC）对孕产妇和新生儿健康构成重大挑战，但其对新生儿结局的影响仍不明确。本系统综述旨在评估与PAC相关的新生儿风险。 方法：系统检索截至2024年11月1日的PubMed、Embase、Scopus等数据库，纳入评估PAC妊娠新生儿结局的观察性研究和随机对照试验。结局指标包括早产、低出生体重、巨大儿、小于或大于胎龄儿、低Apgar评分、先天性畸形及新生儿死亡率。 结果：共纳入11项高质量研究，涵盖超过4600万例分娩，其中9953例为PAC妊娠。PAC显著增加早产（校正OR值范围1.48-6.34）和低出生体重（校正OR值最高达5.5）的风险。其他不良结局包括低Apgar评分和新生儿死亡率，主要与早产相关。癌症类型和治疗时机影响上述结局，妇科癌症和乳腺癌风险更高。 结论：PAC母亲的新生儿不良结局风险显著增加，凸显了个体化多学科管理的重要性。未来需开展前瞻性研究以明确妊娠期特定癌症治疗方案的影响。
Evaluating Offspring After Pregnancy-Associated Cancer: A Systematic Review of Neonatal Outcomes
肿瘤(癌症)患者之家