文章：

HOX基因家族在血液系统及实体肿瘤中作为预后与诊断生物标志物的作用

The HOX Gene Family’s Role as Prognostic and Diagnostic Biomarkers in Hematological and Solid Tumors

原文发布日期：15 January 2025

DOI: 10.3390/cancers17020262

类型: Article

开放获取: 是

英文摘要：

The HOX gene family encodes for regulatory transcription factors that play a crucial role in embryogenesis and differentiation of adult cells. This highly conserved family of genes consists of thirty-nine genes in humans that are located in four clusters, A–D, on different chromosomes. While early studies on the HOX gene family have been focused on embryonic development and its related disorders, research has shifted to examine aberrant expression of HOX genes and the subsequent implication in cancer prediction and progression. Due to their role of encoding master regulatory transcription factors, the abnormal expression of HOX genes has been shown to affect all stages of tumorigenesis and metastasis. This review highlights the novel role of the HOX family’s clinical relevance as both prognostic and diagnostic biomarkers in hematological and solid tumors.

摘要翻译： 

HOX基因家族编码的调控性转录因子在胚胎发生和成体细胞分化中发挥关键作用。这一高度保守的基因家族在人类中包含39个基因，分布于不同染色体的A-D四个基因簇中。早期研究主要聚焦于HOX基因在胚胎发育及相关疾病中的作用，而当前研究已转向探索HOX基因异常表达在癌症预测与进展中的重要意义。作为编码核心调控转录因子的基因家族，HOX基因的异常表达已被证实会影响肿瘤发生和转移的所有阶段。本综述重点阐述HOX基因家族作为血液肿瘤和实体瘤预后与诊断生物标志物的临床相关性新进展。

原文链接：

The HOX Gene Family’s Role as Prognostic and Diagnostic Biomarkers in Hematological and Solid Tumors