文章：

泌尿生殖系统癌症全身治疗中皮肤毒性的诊断与管理

Diagnosis and Management of Skin Toxicities in Systemic Treatment of Genitourinary Cancers

原文发布日期：14 January 2025

DOI: 10.3390/cancers17020251

类型: Article

开放获取: 是

英文摘要：

The landscape of available therapeutic options for treatment of genitourinary (GU) cancers is expanding dramatically. Many of these treatments have distinct, sometimes severe, skin toxicities including morbilliform, bullous, pustular, lichenoid, eczematous, psoriasiform, and palmoplantar eruptions. Pruritus and skin pigmentation changes have also been noted. This review aims to synthesize dermatologic events observed with antibody drug conjugates, poly (ADP-ribose) polymerase (PARP) inhibitors, androgen receptor pathway inhibitors, tyrosine kinase inhibitors, immune checkpoint inhibitors, and the combination of these agents used for the treatment of GU cancers. It provides a guide on diagnosis and initial management of these rashes for medical oncologists.

摘要翻译： 

泌尿生殖系统癌症的治疗选择范围正在显著扩大。许多治疗方法会引发独特且有时严重的皮肤毒性反应，包括麻疹样、大疱性、脓疱性、苔藓样、湿疹样、银屑病样及掌跖皮疹等皮肤表现。瘙痒和皮肤色素沉着改变也已被观察到。本综述旨在系统总结抗体药物偶联物、聚腺苷二磷酸核糖聚合酶抑制剂、雄激素受体通路抑制剂、酪氨酸激酶抑制剂、免疫检查点抑制剂以及这些药物联合治疗泌尿生殖系统癌症时观察到的皮肤不良事件，并为肿瘤内科医生提供相关皮疹的诊断和初步处理指南。

原文链接：

Diagnosis and Management of Skin Toxicities in Systemic Treatment of Genitourinary Cancers