Background/Objectives: This study pioneers the application of the ViPLUS module, utilizing plane-wave ultrasound to measure breast tissue viscosity and elasticity. The primary goal was to establish normal reference values for viscosity in healthy women. Secondary objectives included exploring correlations between breast tissue viscosity and breast density categories, hormonal influences, and menstrual cycle phases. Methods: A prospective study was conducted on 245 asymptomatic women. Viscosity and elasticity measurements were obtained using the ViPLUS module, ensuring high reliability with stringent quality control measures. Data were statistically analyzed to evaluate correlations and group differences. Results: The median viscosity value for normal breast parenchyma was 1.7 Pa.s, with no significant variations based on breast density, menopausal status, or menstrual cycle phase. A strong correlation (rho = 0.866,p< 0.001) was observed between elasticity and viscosity values. Conclusions: The findings suggest that breast viscosity is consistent across diverse physiological states, indicating its potential as an independent diagnostic marker. This parameter could be pivotal in future breast cancer screening strategies, especially for younger women and those with dense breasts.
**背景/目的：** 本研究开创性地应用ViPLUS模块，利用平面波超声技术测量乳腺组织的粘度和弹性。主要目标是建立健康女性乳腺粘度的正常参考值。次要目标包括探讨乳腺组织粘度与乳腺密度分类、激素影响以及月经周期阶段之间的相关性。 **方法：** 对245名无症状女性进行了一项前瞻性研究。使用ViPLUS模块获取粘度和弹性测量值，并通过严格的质量控制措施确保高可靠性。对数据进行统计分析，以评估相关性和组间差异。 **结果：** 正常乳腺实质的中位粘度值为1.7 Pa.s，且未发现其与乳腺密度、绝经状态或月经周期阶段存在显著差异。在弹性值与粘度值之间观察到强相关性（rho = 0.866, p < 0.001）。 **结论：** 研究结果表明，乳腺粘度在不同生理状态下保持一致，提示其有潜力成为一个独立的诊断标志物。该参数可能在未来的乳腺癌筛查策略中发挥关键作用，特别是对于年轻女性和致密型乳腺女性。
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